Granulocyte colony‐stimulating factor and its potential application for skeletal muscle repair and regeneration

CR Wright, AC Ward, AP Russell - Mediators of inflammation, 2017 - Wiley Online Library
Granulocyte colony‐stimulating factor (G‐CSF) was originally discovered in the context of
hematopoiesis. However, the identification of the G‐CSF receptor (G‐CSFR) being …

Regulation of granulocyte colony-stimulating factor and its receptor in skeletal muscle is dependent upon the type of inflammatory stimulus

CR Wright, EL Brown, PA Della Gatta… - Journal of Interferon & …, 2015 - liebertpub.com
The cytokine granulocyte colony-stimulating factor (G-CSF) binds to its receptor (G-CSFR) to
stimulate hematopoietic stem cell mobilization, myelopoiesis, and the production and …

[HTML][HTML] G-CSF does not influence C2C12 myogenesis despite receptor expression in healthy and dystrophic skeletal muscle

CR Wright, EL Brown, PA Della-Gatta, AC Ward… - Frontiers in …, 2014 - frontiersin.org
Granulocyte-colony stimulating factor (G-CSF) increases recovery of rodent skeletal muscles
after injury, and increases muscle function in rodent models of neuromuscular disease …

Granulocyte-colony stimulating factor enhances muscle proliferation and strength following skeletal muscle injury in rats

I Stratos, R Rotter, C Eipel… - Journal of Applied …, 2007 - journals.physiology.org
Insufficiency of skeletal muscle regeneration often impedes the healing process with
functional deficiencies and scar formation. We tested the hematopoietic growth factor …

G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation

M Hara, S Yuasa, K Shimoji, T Onizuka… - Journal of Experimental …, 2011 - rupress.org
After skeletal muscle injury, neutrophils, monocytes, and macrophages infiltrate the
damaged area; this is followed by rapid proliferation of myoblasts derived from muscle stem …

Critical role for granulocyte colony-stimulating factor in inflammatory arthritis

KE Lawlor, IK Campbell, D Metcalf… - Proceedings of the …, 2004 - National Acad Sciences
Granulocyte colony-stimulating factor (G-CSF) is a well known regulator of granulopoiesis,
but the role of endogenous G-CSF in inflammatory joint disease has not been explored. We …

Targeting GM-CSF in inflammatory diseases

IP Wicks, AW Roberts - Nature Reviews Rheumatology, 2016 - nature.com
Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth factor first
identified as an inducer of differentiation and proliferation of granulocytes and macrophages …

G-CSF: function and modes of action

S Basu, A Dunn, A Ward - International journal of …, 2002 - spandidos-publications.com
Since the observations in the 1960s that granulocyte-colony stimulating factor (G-CSF)
stimulated the proliferation of granulocytic cells in semisolid cultures of bone marrow cells, G …

Targeting GM-CSF in inflammatory and autoimmune disorders

AA Achuthan, KMC Lee, JA Hamilton - Seminars in immunology, 2021 - Elsevier
Granulocyte macrophage-colony stimulating factor (GM-CSF) was originally identified as a
growth factor for its ability to promote the proliferation and differentiation in vitro of bone …

[HTML][HTML] GM-CSF in inflammation

JA Hamilton - Journal of Experimental Medicine, 2020 - rupress.org
Granulocyte–macrophage colony-stimulating factor (GM-CSF) has many more functions
than its original in vitro identification as an inducer of granulocyte and macrophage …