Simple Summary Induced pluripotent stem cells (iPSCs) are crucial for disease modeling
and cell-based therapy because they serve as an infinite source of specific human cell …

Pluripotent stem cells offer unique avenues to study human-specific aspects of disease and
are a highly versatile tool in cancer research. Oncogenic processes and developmental …

Nervous system tumors, particularly brain tumors, represent the most common tumors in
children and one of the most lethal tumors in adults. Despite decades of research, there are …

Over the past decade, the use of induced pluripotent stem cells (IPSCs), as both direct
therapeutics and building blocks for 3D in vitro models, has exhibited exciting potential in …

Together with recent advances in the processing and culture of human tissue,
bioengineering, xenotransplantation and genome editing, Induced pluripotent stem cells …

Abstract In 2006, Noble Prize laureate Shinya Yamanaka discovered that a set of
transcription factors can reprogram terminally differentiated somatic cells to a pluripotent …

The elucidation of cancer pathogenesis has been hindered by limited access to patient
samples, tumor heterogeneity, and the lack of reliable model organisms. Characterized by …

Brain diseases affect 1 in 6 people worldwide. These diseases range from acute
neurological conditions such as stroke to chronic neurodegenerative disorders such as …

One of the most profound advances in the last decade of biomedical research has been the
development of human induced pluripotent stem cell (hiPSC) models for identification of …

There is great need to develop more predictive drug discovery tools to identify new therapies
to treat diseases of the central nervous system (CNS). Current nonpluripotent stem cell …