The Human Leukocyte Antigen Class I Region Is Associated with EBV-Positive Hodgkin's Lymphoma: HLA-A and HLA Complex Group 9 Are Putative Candidate …

M Niens, A Van Den Berg, A Diepstra, IM Nolte… - … Biomarkers & Prevention, 2006 - AACR
Various studies have indicated that the human leukocyte antigen (HLA) region is associated
with Hodgkin's lymphoma. We recently showed a specific association of the HLA class I …

Modeling HLA associations with EBV‐positive and‐negative H odgkin lymphoma suggests distinct mechanisms in disease pathogenesis

PCD Johnson, KA McAulay… - … Journal of Cancer, 2015 - Wiley Online Library
HLA genotyping and genome wide association studies provide strong evidence for
associations between Human Leukocyte Antigen (HLA) alleles and classical Hodgkin …

Multiple Hodgkin lymphoma–associated loci within the HLA region at chromosome 6p21. 3

L Moutsianas, V Enciso-Mora, YP Ma… - Blood, The Journal …, 2011 - ashpublications.org
Since an association between the human leukocyte antigen (HLA) region and Hodgkin
lymphoma (HL) was first reported in 1967, many studies have reported associations …

[HTML][HTML] HLA associations in classical Hodgkin lymphoma: EBV status matters

X Huang, K Kushekhar, I Nolte, W Kooistra, L Visser… - PloS one, 2012 - journals.plos.org
The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic
factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a …

HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma

M Niens, RF Jarrett, B Hepkema… - Blood, The Journal …, 2007 - ashpublications.org
Previous studies showed that the HLA class I region is associated with Epstein-Barr virus
(EBV)–positive Hodgkin lymphoma (HL) and that HLA-A is the most likely candidate gene in …

Human leukocyte antigens and genetic susceptibility to lymphoma

KA McAulay, RF Jarrett - Tissue Antigens, 2015 - Wiley Online Library
Familial aggregation, coupled with ethnic variation in incidence, suggests that inherited
susceptibility plays a role in the development of lymphoma, and the search for genetic risk …

Genetic susceptibility to Hodgkin's lymphoma associated with the human leukocyte antigen region

A Diepstra, M Niens, GJ Te Meerman… - European Journal of …, 2005 - Wiley Online Library
Based on the presence of an abundant inflammatory infiltrate, expression of a broad
spectrum of cytokines and the professional antigen presenting phenotype of Hodgkin Reed …

Genome-wide association study of classical Hodgkin lymphoma and Epstein–Barr virus status–defined subgroups

KY Urayama, RF Jarrett, H Hjalgrim… - Journal of the …, 2012 - academic.oup.com
Background Accumulating evidence suggests that risk factors for classical Hodgkin
lymphoma (cHL) differ by tumor Epstein–Barr virus (EBV) status. This potential etiological …

A Novel Risk Locus at 6p21. 3 for Epstein–Barr Virus-Positive Hodgkin Lymphoma

M Delahaye-Sourdeix, KY Urayama, V Gaborieau… - … Biomarkers & Prevention, 2015 - AACR
Background: A proportion of the genetic variants involved in susceptibility to Hodgkin
lymphoma differ by the tumor's Epstein–Barr virus (EBV) status, particularly within the MHC …

Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma

A Diepstra, M Niens, E Vellenga, GW Van Imhoff… - The Lancet, 2005 - thelancet.com
Summary Background Associations of Hodgkin's lymphoma with HLA have been reported
for many years. In 20–40% of patients with this disorder, Epstein-Barr virus (EBV) is present …