Unlike cardiac and skeletal muscle, little is known about vascular smooth muscle
mitochondrial respiration. Therefore, the present study examined mitochondrial respiratory …

During exercise, muscle ATP demand increases with intensity, and at the highest power
output, ATP consumption may increase more than 100-fold above the resting level. The rate …

Mitochondria are the metabolic powerhouses of cells. In addition to generating adenosine
triphosphate (ATP), they play important roles in cell survival pathways such as apoptosis …

Exercise training is recognized to improve cardiac and skeletal muscle mitochondrial
respiratory capacity; however, the impact of chronic exercise on vascular mitochondrial …

Investigations on the mechanisms capable of influencing heart mitochondrial function
constitute a central contribution to the understanding of cardiac bioenergetics. In contrast to …

Maximal ADP-stimulated mitochondrial respiration depends on convergent electron flow
through Complexes I+ II to the Q-junction of the electron transport system (ETS). In most …

In peripheral vascular disease, impaired muscle energy metabolism is assumed to be due
mainly to defective vascular O2 supply, the resulting cellular hypoxia inhibiting oxidative …

Although striated muscles differ in mitochondrial content, the extent of fiber-type specific
mitochondrial specializations is not well known. To address this issue, we compared …

Heart failure (HF) is a complex chronic clinical syndrome. Energy deficit is considered to be
a key contributor to the development of both cardiac and skeletal myopathy. In HF, several …

Irrespective of the organ involved, restoration of blood flow to ischemic tissue is vital,
although reperfusion per se is deleterious. In the setting of vascular surgery, even subtle …