New Findings• What is the topic of this review? Muscle dysfunction is a common
complication and an important independent prognostic factor in chronic obstructive …

Mitochondria utilize the majority of oxygen (O2) consumed by aerobic organisms as the final
electron acceptor for oxidative phosphorylation (OXPHOS) but also to generate reactive …

Cardiac performance depends on a fine balance between the work the heart has to perform
to satisfy the needs of the body and the energy that it is able to produce. Thus, energy …

It is difficult to estimate the maximum in vivo aerobic ATP production rate of the intact heart
independent of limitations imposed by blood flow, oxygen delivery, and maximum …

Techniques and protocols of assessment of mitochondrial properties are of physiological
and physiopathological important significance. A precise knowledge of the advantages and …

Mitochondria are dynamic organelles which adapt their morphology by fusion and fission
events to the bioenergetic requirements of the cell. Cardiac and skeletal muscles are tissues …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

Evidence suggests that the peak skeletal muscle mitochondrial ATP synthesis rate (V max)
in patients with peripheral artery disease (PAD) may be attenuated due to disease-related …

This study tested the hypotheses that skeletal muscle mitochondrial ATP production rate
(MAPR) is impaired in patients with peripheral arterial disease (PAD) and that it relates …

Several inherited and acquired disorders of mitochondria lead to defects in cardiac function
as reflected in exercise intolerance, arrhythmias and heart failure. Manifestations of …