Across a wide range of species and body mass a close matching exists between maximal
conductive oxygen delivery and mitochondrial respiratory rate. In this study we investigated …

Over the past decade, mitochondria have emerged as critical integrators of energy
production, generation of reactive oxygen species (ROS), multiple cell death, and signaling …

Mitochondrial activity warrants energy supply to oxidative myofibres to sustain endurance
workload. The maintenance of mitochondrial homeostasis is ensured by the control of fission …

Mitochondria influence cardiac electrophysiology through energy-and redox-sensitive ion
channels in the sarcolemma, with the collapse of energetics believed to be centrally …

Years ago a debate arose as to whether two functionally different mitochondrial
subpopulations, subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM) …

In striated muscle the coupling of blood flow to changes in tissue metabolism is
hypothesized to be dependent in part on release of vasodilating metabolic by-products …

The coupling of mitochondrial ATP synthesis and oxygen consumption (ratio of ATP and
oxygen fluxes, P/O) plays a central role in cellular bioenergetics. Reduced P/O values are …

New Findings• What is the central question of this study? Do mouse skeletal muscle
mitochondria resemble human skeletal muscle mitochondria sufficiently to serve as a proper …

The effects of mitochondrial uncoupling on skeletal muscle mitochondrial adaptation and
maximal exercise capacity are unknown. In this study, rats were divided into a control group …

Mitochondrial bioenergetic contributions to sex differences in human skeletal muscle
metabolism remain poorly defined. The primary aim of this study was to determine whether …