Aims/hypothesis Self-antigen-specific T cell responses drive type 1 diabetes pathogenesis,
but alterations in innate immune responses are also critical and not as well understood …

Type 1 diabetes development in the NOD mouse model is widely reported to be dependent
on high-level production by autoreactive CD4+ and CD8+ T cells of interferon-γ (IFN-γ) …

We demonstrate diverse roles of IFN-γ in the induction and regulation of immune-mediated
inflammation using a transfer model of autoimmune diabetes. The diabetogenic CD4+ …

Purpose Aberrant regulation of innate immune cells such as macrophages has been
implicated in the onset and progression of type 1 diabetes (T1D). Macrophages from …

Abstract Purpose of Review Despite immense research efforts, type 1 diabetes (T1D)
remains an autoimmune disease without a known trigger or approved intervention. Over the …

Aims/hypothesis We sought to determine whether the presence of natural autoreactive
antibodies of B1a cell origin would play a role in the initiation of type 1 diabetes. Methods …

Type 1 diabetes (T1D) is an organ-specific autoimmune disease resulting from the specific
destruction of insulin-producing pancreatic β-cells, culminating in a state of hypoinsulinemia …

IFN‐γ is generally believed to be important in the autoimmune pathogenesis of type 1
diabetes (T 1 D). However, the development of spontaneous β‐cell autoimmunity is …

IL-12 administration to nonobese diabetic (NOD) mice induces IFN-γ-secreting type 1 T cells
and high circulating IFN-γ levels and accelerates insulin-dependent diabetes mellitus …

Previous results indicate the presence of an interferon (IFN) signature in type 1 diabetes
(T1D), capable of inducing chronic inflammation and compromising b cell function. Here, we …