Evolution of polyketide synthesis in a Dothideomycete forest pathogen

IK Ozturk, P Chettri, PY Dupont, I Barnes… - Fungal Genetics and …, 2017 - Elsevier
Fungal secondary metabolites have many important biological roles and some, like the toxic
polyketide aflatoxin, have been intensively studied at the genetic level. Complete sets of …

Integration of chemical, genetic, and bioinformatic approaches delineates fungal polyketide–peptide hybrid biosynthesis

M Yokoyama, Y Hirayama, T Yamamoto… - Organic …, 2017 - ACS Publications
To identify natural products and their associated biosynthetic genes from underutilized,
difficult-to-manipulate microbes, chemical screening and bioinformatic analysis were …

Assembly of high‐quality genomes of the locoweed Oxytropis ochrocephala and its endophyte Alternaria oxytropis provides new evidence for their symbiotic …

L Zhang, R Wu, LAJ Mur, C Guo, X Zhao… - Molecular Ecology …, 2023 - Wiley Online Library
Locoweeds are perennial forbs poisonous to livestock and cause extreme losses to animal
husbandry. Locoweed toxicity is attributed to the symbiotic endophytes in Alternaria sect …

Polyketide Synthase and Nonribosomal Peptide Synthetase Gene Clusters in Type Strains of the Genus Phytohabitans

H Komaki, T Tamura - Life, 2020 - mdpi.com
(1) Background: Phytohabitans is a recently established genus belonging to rare
actinomycetes. It has been unclear if its members have the capacity to synthesize diverse …

Polyketide synthases of Diaporthe helianthi and involvement of DhPKS1 in virulence on sunflower

M Ruocco, R Baroncelli, SO Cacciola, C Pane… - BMC genomics, 2018 - Springer
Background The early phases of Diaporthe helianthi pathogenesis on sunflower are
characterized by the production of phytotoxins that may play a role in host colonisation. In …

Polyketide synthase–nonribosomal peptide synthetase hybrid enzymes of fungi

S Kishimoto, Y Hirayama, K Watanabe - Physiology and Genetics …, 2018 - Springer
Fungi are known to produce various nonribosomal peptide-derived compounds that exhibit
useful bioactivities. However, understanding of how those fungal secondary metabolites are …

Functional Analysis of All Nonribosomal Peptide Synthetases in Cochliobolus heterostrophus Reveals a Factor, NPS6, Involved in Virulence and Resistance to …

BN Lee, S Kroken, DYT Chou, B Robbertse… - Eukaryotic …, 2005 - Am Soc Microbiol
Nonribosomal peptides, made by nonribosomal peptide synthetases, have diverse
biological activities, including roles as fungal virulence effectors. Inspection of the genome of …

Identification of the nonribosomal peptide synthetase gene responsible for bassianolide synthesis in wood-decaying fungus Xylaria sp. BCC1067

J Jirakkakul, J Punya, S Pongpattanakitshote… - …, 2008 - microbiologyresearch.org
Intensive study of gene diversity of bioactive compounds in a wood-rot fungus, Xylaria sp.
BCC1067, has made it possible to identify polyketides and nonribosomal peptides (NRPs) …

Efficient disruption of a polyketide synthase gene (pks1) required for melanin synthesis through Agrobacterium-mediated transformation of Glarea lozoyensis

A Zhang, P Lu, AM Dahl-Roshak, PS Paress… - Molecular Genetics and …, 2003 - Springer
Glarea lozoyensis produces pneumocandin B 0, a potent inhibitor of fungal glucan
synthesis. This industrially important filamentous fungus is slow-growing, is very darkly …

Genomic and transcriptomic analysis of the endophytic fungus Pestalotiopsis fici reveals its lifestyle and high potential for synthesis of natural products

X Wang, X Zhang, L Liu, M Xiang, W Wang, X Sun… - BMC genomics, 2015 - Springer
Background In recent years, the genus Pestalotiopsis is receiving increasing attention, not
only because of its economic impact as a plant pathogen but also as a commonly isolated …