Replacement of diseased organs with transplanted healthy donor ones remains the best
and often only treatment option for end-stage organ disease. Immunosuppressants have …

Regulatory T cells (Treg) may play an important role in operational (clinical) tolerance (OT),
a stable graft function without immunosuppression in an otherwise immunocompetent host …

Kidney transplantation is the most common solid organ transplant and the best current
therapy for end-stage kidney failure. However, with standard immunosuppression, most …

Transplantation is limited by the need for life-long pharmacological immunosuppression,
which carries significant morbidity and mortality. Regulatory T cell (Treg) therapy holds …

With the recent findings, we have gained a better understanding of Treg heterogeneity,
plasticity and function. Using the outcomes of clinical trials in stem cell transplantation, we …

Adoptive transfer of T regulatory cells (Tregs) is of great interest as a novel
immunosuppressive therapy in autoimmune disorders and transplantation. Obtaining a …

Adoptive transfer of regulatory T cells (Tregs) is an exciting and promising strategy for
suppressing undesired immune responses during transplantation. Preclinical and clinical …

Isolated regulatory T cells (Tregs) are expanded in vitro using anti-CD3/anti-CD28 beads
(activation/proliferation) and IL-2 (survival). Polyclonal Tregs are reintroduced into patients …

Long-term tolerance is potentially an ideal in organ transplant. Achieving this leads us to
eliminate immunosuppressive therapies and their associated side effects. Although most …

Regulatory T cells (Tregs) are thought to be pivotal in controlling both autoimmune and
allogeneic undesired immune responses. Recently, an extensive effort has been devoted to …