The therapeutic usage of cilostazol is limited owing to its poor aqueous solubility and oral
bioavailability. Our aim was to produce cilostazol crystals with small average particle size; …

Improvement in dissolution of the drugs having poor solubility is a challenge in
pharmaceutical industry. Micronization is one technique, employed for dissolution …

The objectives of this study are to enhance the oral bioavailability of cilostazol (CLZ), which
is a poorly soluble compound, by cocrystallization and to evaluate the correlation between …

Materials and Methods: Cilostazol agglomerates were prepared using various polymers with
varying concentration of hydroxypropyl methylcellulose E 50 (HPMC E50), polyvinyl …

The cocrystal formation of pharmaceuticals can improve the various physical properties of
drugs, such as solubility, without the need for chemical modification of the drug substances …

Purpose The purpose of this study is to achieve enhanced solubility of cilostazol (CLT) by
nanocrystal (NC) formation. CLT-NC was prepared by nanoprecipitation without the use of …

Purpose: The aim of this study was to develop cilostazol (CLT) nanocrystals intended to
improve its dissolution rate and enhance its bioavailability. Methods: In this study, CLT …

Cilostazol is practically insoluble in water and thus results in poor bioavailability. Only a few
approaches have been reported for improving the bioavailability of cilostazol. Solid …

The aim of this new work was to improve the dissolution rate of poorly water-soluble
cilostazol (CLT) by adsorbing dissolved drug molecules onto the surface of undissolved …

A growing number of poorly water-soluble drug have been discovered, but the poor
bioavailability is a critical problem. In this study, physical properties and dissolution profiles …