Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in …

QQ Mao, YF Xian, SP Ip, SH Tsai, CT Che - Behavioural brain research, 2010 - Elsevier
The root part of Paeonia lactiflora Pall., commonly known as peony, is a commonly used
Chinese herb for the treatment of depression-like disorders. Previous studies in our …

Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and …

QQ Mao, SP Ip, KM Ko, SH Tsai, CT Che - Progress in Neuro …, 2009 - Elsevier
The root part of Paeonia lactiflora Pall.(Ranunculaceae), commonly known as peony, is a
commonly used Chinese herb for the treatment of depression-like disorders. Previous …

Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats

QQ Mao, Z Huang, SP Ip, YF Xian, CT Che - Behavioural Brain Research, 2012 - Elsevier
Repeated injections of corticosterone (CORT) induce the dysregulation of the hypothalamic-
pituitary-adrenal (HPA) axis, resulting in depressive-like behavior. This study aimed to …

Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice

LT Yi, J Li, D Geng, BB Liu, Y Fu, JQ Tu, Y Liu… - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Perilla frutescens (Perilla leaf), a traditional
Chinese medicinal herb, has been used for centuries to treat various conditions including …

Effects of peony glycosides on mice exposed to chronic unpredictable stress: further evidence for antidepressant-like activity

QQ Mao, SP Ip, KM Ko, SH Tsai, YF Xian… - Journal of …, 2009 - Elsevier
ETHNOPHARMACOLOGY RELEVANCE: Peony, the processed root of Paeonia lactiflora
Pall.(Ranunculaceae), is a component herb of many traditional formulae for the treatment of …

Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress

FM Qiu, XM Zhong, QQ Mao, Z Huang - Neuroscience Letters, 2013 - Elsevier
We have previously demonstrated that the total glycosides of peony exert antidepressant-
like effects in animal models. Paeoniflorin is the main active glycoside of peony. The …

Antidepressant-like effect of peony glycosides in mice

QQ Mao, SP Ip, SH Tsai, CT Che - Journal of ethnopharmacology, 2008 - Elsevier
AIM OF THE STUDY: The root part of Paeonia lactiflora Pall.(Ranunculaceae), known as
peony, is often used in Chinese herbal formulae for the treatment of depression-like …

Paeoniflorin attenuates impairment of spatial learning and hippocampal long-term potentiation in mice subjected to chronic unpredictable mild stress

SC Liu, WY Hu, WY Zhang, L Yang, Y Li, ZC Xiao… - …, 2019 - Springer
Rationale and objective Paeoniflorin has been reported to exhibit antidepressant-like effects
in several animal model depression; and it also exerts a neuroprotective effect. In the …

BDNF signaling is necessary for the antidepressant-like effect of naringenin

LT Yi, BB Liu, J Li, L Luo, Q Liu, D Geng, Y Tang… - Progress in Neuro …, 2014 - Elsevier
Previous studies in our laboratory have demonstrated that naringenin produced
antidepressant-like action in tail suspension test (TST). However, the underlying …

Neotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and synaptophysin expression in rat

J Luo, L Zhang, N Ning, H Jiang, SY Yu - Behavioural brain research, 2013 - Elsevier
Depression is one of the most common neuropsychiatric disorders and has been associated
with a wide range of neuronal structural changes in brain regions. Neotrofin, a neurotrophin …