Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α are master transcription factors that
regulate cellular responses to hypoxia, but the exact function in regulatory T (Treg) cells is …

Hypoxia-inducible factor 1α (HIF-1α) regulates cellular responses to hypoxia. However,
conflicting roles for HIF-1α in the functions of regulatory T cells (Tregs) have been reported …

Recent data suggest that hypoxia and its principal molecular signature HIF‐1 (hypoxia‐
inducing factor‐1) may tune down inflammation by dictating anti‐inflammatory programs. We …

Tissue hypoxia can occur in physiological and pathological conditions. When O 2 availability
decreases, the transcription factor hypoxia-inducible factor (HIF)-1α is stabilized and …

To evaluate the role of hypoxia-inducible factor 1α (HIF-1α) and its TCR activation-inducible
short isoform I. 1 in T cell functions, we genetically engineered unique mice with: 1) knockout …

Recent studies have demonstrated dramatic shifts in metabolic supply-and-demand ratios
during inflammation, a process resulting in localized tissue hypoxia within inflammatory …

T cell differentiation into distinct functional effector and inhibitory subsets is regulated, in
part, by the cytokine environment present at the time of antigen recognition. Here, we show …

Summary Foxp3+ regulatory T (Treg) cells play a critical role in immune homeostasis;
however, the mechanisms to maintain their function remain unclear. Here, we report that the …

Application of regulatory T cells (Tregs) in transplantation, autoimmunity and allergy has
been extensively explored, but how Foxp3 and Treg stability is regulated in vivo is …

Abstract Differentiation of regulatory Treg (Treg) in the periphery is critical to control
inflammatory processes. Although polarization of inducible Treg (iTreg) often occurs in an …