Superantigens (SAgs) are microbial toxins defined by their ability to activate T lymphocytes
in a T cell receptor (TCR) β-chain variable domain (Vβ)-specific manner. Although existing …

Bacterial superantigens (SAgs) constitute a large family of bacterial toxins that share the
capacity to induce massive activation of the human immune system. Such a feature is based …

▪ Abstract Superantigens (SAGs) are a class of immunostimulatory and disease-causing
proteins of bacterial or viral origin with the ability to activate large fractions (5–20%) of the T …

Bacterial superantigens (SAgs) bind to major histocompatibility complex (MHC) class II
molecules and activate T cells in a Vβ-restricted fashion. We recently identified subsets of …

Superantigens (SAGs) interact with host immune receptors to induce a massive release of
inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can …

Superantigens activate large fractions of T cells through unconventional interactions with
both TCR β-chain V domains (Vβs) and MHC class II molecules. The bacterial superantigen …

Bacterial superantigens (SAg) are exotoxins from pathogens which interact with innate and
adaptive immune cells. The paradox that SAgs cause activation and inactivation/anergy of T …

Bacterial T cell superantigens (SAgs) are a family of microbial exotoxins that function to
activate large numbers of T cells simultaneously. SAgs activate T cells by direct binding and …

Superantigens (SAGs) bind simultaneously to major histocompatibility complex (MHC) and T‐
cell receptor (TCR) molecules, resulting in the massive release of inflammatory cytokines …

Superantigens (SAgs) are microbial toxins that bind to both TCR β-chain variable domains
(Vβs) and MHC class II molecules, resulting in the activation of T cells in a Vβ-specific …