We have engineered polymer-based microenvironments that promote vasculogenesis both
in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly (ethyl …

Synergy in the downstream signaling pathways of the vascular endothelial growth factor
receptor-2 (VEGFR-2) and the integrin αvβ3 is critical for blood vessel formation. Thus …

Integrin binding to bioengineered hydrogel scaffolds is essential for tissue regrowth and
regeneration, yet not all integrin binding can lead to tissue repair. Here, we show that …

Therapeutic angiogenesis relies on the delivery of angiogenic factors capable of reversing
tissue ischemia. Polymeric materials that can provide spatial and temporal over vascular …

Vascular endothelial growth factor (VEGF) has been extensively investigated to promote
vascularization at damaged or diseased sites and in tissue implants. Here we are interested …

Clinical trials of therapeutic angiogenesis by vascular endothelial growth factor (VEGF) gene
delivery failed to show efficacy. Major challenges include the need to precisely control in …

Blood vessel growth plays a key role in regenerative medicine, both to restore blood supply
to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered …

Local, controlled induction of angiogenesis remains a challenge that limits tissue
engineering approaches to replace or restore diseased tissues. We present a new class of …

Long‐term survival and success of artificial tissue constructs depend greatly on
vascularization. Endothelial‐cell (EC) differentiation and vasculature formation are …

Creating a long‐lasting and functional vasculature represents one of the most fundamental
challenges in tissue engineering. VEGF has been widely accepted as a potent angiogenic …