The increasing prevalence of obesity and metabolic diseases is a worldwide public health
concern, and the advent of new analytical technologies has made it possible to highlight the …

Sphingolipids have emerged as key signaling molecules involved in the regulation of a
variety of cellular functions including cell growth and differentiation, proliferation and …

Metabolic disease, including obesity and type 2 diabetes, constitutes a major emerging
health crisis in Western nations. Although the symptoms and clinical pathology and …

Cardiovascular diseases (CVDs) are the leading cause of death and illness in Europe and
worldwide, responsible for a staggering 47% of deaths in Europe. Over the past few years …

Sphingolipids are a family of lipid molecules produced through different pathways in
mammals. Sphingolipids are structural components of membranes, but in response to …

Sphingolipids are a class of lipids with high structural diversity and biological pleiotropy.
Mounting evidence supports a role for sphingolipids in regulating pathophysiology of …

Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …

Pharmacological interference with sphingolipid metabolizing enzymes promises to provide
novel ways to modulate cellular pathways relevant in multiple diseases. In this review, we …

Sphingolipids, ubiquitously produced in all vertebrate cells, are biologically active lipids that
are the structural components of cell membranes. They also function as intracellular and …

Atherosclerosis is the major cause of mortality in the developed countries. Although
presently known risk factors have some predictive value for the disease, a major part of the …