The design of novel drugs for pain relief with improved analgesic properties and diminished
side effect induction profile still remains a challenging pursuit. Tolerance is one of the most …

On the basis of the structure− activity relationships of δ-opioid-selective peptide ligands and
on a model of the proposed bioactive conformation for a potent and selective …

Diverse chemical and pharmacological strategies are currently being explored to minimize
the unwanted side effects of currently used opioid analgesics while achieving effective pain …

Herein, the opioid pharmacophore H-Dmt-d-Arg-Aba-β-Ala-NH2 (7) was linked to peptide
ligands for the nociceptin receptor. Combination of 7 and NOP ligands (eg, H-Arg-Tyr-Tyr …

The optimization and truncation of our lead peptide-derived ligand TY005 possessing eight
amino-acid residues was performed. Among the synthesized derivatives, NP30 (Tyr 1-DAla …

Reducing the well-known side effects of opioids prescribed to treat chronic pain remains
unresolved, despite extensive research in this field. Among several options to tackle this …

Morphine, which acts through opioid receptors, is one of the most efficient analgesics for the
alleviation of severe pain. However, its usefulness is limited by serious side effects …

Opioid narcotics are used for the treatment of moderate-to-severe pain and primarily exert
their analgesic effects through μ receptors. Although traditional μ agonists can cause …

Addiction to conventional opioid pain analgesics is a major societal problem that is
increasing at an alarming rate. New drugs to combat the effects of opioid abuse are …

Opioid compounds with mixed μ agonist/δ antagonist properties could be used as
analgesics with low propensity to induce tolerance and dependence. Here we report the …