Introduction Despite the great therapeutic potential of gene therapy for treating critical
diseases, the clinical application is limited by lack of safe and effective gene delivery …

Background: Gene delivery is a promising technology for treating diseases linked to
abnormal gene expression. Since nucleic acids are the therapeutic entities in such …

Lack of safe, efficient and controllable methods for delivering therapeutic genes appears to
be the most important factor preventing human gene therapy. Safety issues encountered …

Gene therapy is a promising strategy for treatments of various diseases. Efficient and safe
introduction of therapeutic genes into targeted cells is essential to realize functions of the …

Introduction: Branched and linear polyethylenimines (PEIs) are cationic polymers that have
been used to deliver nucleic acids both in vitro and in vivo. Owing to the high cationic …

Gene therapy has become a promising strategy for the treatment of many inheritable or
acquired diseases that are currently considered incurable. Non-viral vectors have attracted …

The development of gene delivery vectors with high efficiency and biocompatibility is one of
the key points of gene therapy. A series of polycations were prepared from polyethylenimine …

Transfection by means of non-viral gene delivery vectors is the cornerstone of modern gene
delivery. Despite the resources poured into the development of ever more effective …

Background Efficient gene transfer is a major challenge for non‐viral gene therapy.
Understanding how non‐viral vectors initiate gene expression could lead to the …

Gene therapy, ie, the expression in cells of genetic material with therapeutic activity, holds
great promise for the treatment of human diseases. A delivery vehicle (vector), of either viral …