The gene delivery system is one of the three components of a gene medicine, which is the
bottle neck of current gene therapy. Nonviral vectors offer advantages over the viral system …

Publisher Summary The chapter discusses the family of potent polymers for nucleic acid
delivery, polyethylenimines (PEI). This chapter explores the structure and topology of PEI …

Hydrophobic modification of low molecular weight (LMW) polyethylenimine (PEI) is known to
increase gene transfection efficiency of LMW PEI. However, few studies have explored how …

Five new polyethylenimines (PEI) were synthesized by polymerization of aziridine in
aqueous solution and compared to several commercially available PEI used for gene …

Gene therapy is the manipulation of gene expression patterns in specific cells to treat
genetic and pathological diseases. This manipulation is accomplished by the controlled …

Nonviral gene therapy continues to require novel synthetic vectors to deliver therapeutic
nucleic acids effectively and safely. The majority of synthetic nonviral vectors employed in …

Low molecular weight polyethylenimine (1800 Da, also referred to as oligoethylenimines,
OEI) was modified with amino acids, including two aromatic amino acids (tryptophan …

Polyethylenimine (PEI) has been known as an efficient gene carrier with the highest cationic
charge potential. High transfection efficiency of PEI, along with its cytotoxicity, strongly …

No Heading Purpose. Polyethylenimine (PEI) is among the most efficient nonviral gene
delivery vectors. Its efficiency and cytotoxicity depend on molecular weight, with the 25-kDa …

Gene therapy is a hope for curing many diseases and pathological conditions which are
relatively difficult to treat. However lack of proper gene delivery vehicle is the main limiting …