Recent progress on the fronts of design, formulation and delivery with synthetic vectors has
increased the potential of non-viral approaches to attain therapeutic applications. However …

The low toxicity and efficient gene delivery of polymeric vectors remain the major barrier to
the clinical application of non-viral gene therapy. Here, we present a poly-d, l-succinimide …

Background Polyethylenimine (PEI) is one of the most efficient and versatile non-viral
vectors available for gene delivery. Despite many advantages over viral vectors, PEI is still …

Background Nonviral vectors based on polyethylenimine (PEI) usually contain an excess of
PEI that is not complexed to DNA. Since unbound PEI contributes to cellular and systemic …

Polyethylenimine (PEI) is proving to be an efficient and versatile vector for gene delivery in
vivo. However, a limiting factor is the relatively short duration of gene expression in some …

There is a tremendous progress in the design and synthesis of nano-scaled, non-viral
carriers in the previous two decades. The nanodelivery systems can significantly improve …

An objective of designing molecular vehicles exhibiting virus-like transgene delivery
capabilities but with low toxicity and immunogenicity continues to drive synthetic vector …

Purpose Polymeric nucleic acid carriers are designed to overcome one or more barriers to
delivery. High molecular weight polyethylenimine (PEI) shows high transfection efficiency …

Polyethylenimine (PEI) is a gene carrier with high transfection efficiency. However, PEI has
high cytotoxicity, which depends on its molecular weight. To reduce the cytotoxicity …

Abstract Background Polyethylenimines (PEIs) are among the most efficient non‐viral gene
transfer agents developed so far. However, transfections with these polymers were shown to …