[HTML][HTML] A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease

D González-Serna, E Ochoa, E López-Isac, A Julià… - Scientific reports, 2020 - nature.com
Genome-wide association studies (GWASs) have identified a number of genetic risk loci
associated with systemic sclerosis (SSc) and Crohn's disease (CD), some of which confer …

[HTML][HTML] Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease

K Wang, H Zhang, S Kugathasan, V Annese… - The American Journal of …, 2009 - cell.com
Previous genome-wide association (GWA) studies typically focus on single-locus analysis,
which may not have the power to detect the majority of genuinely associated loci. Here, we …

[HTML][HTML] Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci

D Ellinghaus, E Ellinghaus, RP Nair, PE Stuart… - The American Journal of …, 2012 - cell.com
Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically,
pathologically, and therapeutically connected, but little is known about their shared genetic …

Association study of 71 European Crohn's disease susceptibility loci in a Japanese population

A Hirano, K Yamazaki, J Umeno… - Inflammatory bowel …, 2013 - academic.oup.com
Background A large-scale meta-analysis of a series of European genome-wide association
studies revealed 71 susceptibility loci for Crohn's disease (CD). However, it is not clear …

[HTML][HTML] Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases

Y Yang, H Musco, S Simpson-Yap, Z Zhu… - Nature …, 2021 - nature.com
An epidemiological association between multiple sclerosis (MS) and inflammatory bowel
disease (IBD) is well established, but whether this reflects a shared genetic aetiology, and …

Genome-wide Association Study Signal at the 12q12 Locus for Crohn's Disease May Represent Associations with the MUC19 Gene

V Kumar, DR Mack, V Marcil, D Israel… - Inflammatory bowel …, 2013 - academic.oup.com
Background Genome-wide association studies (GWAS) in Crohn's disease (CD) have
identified associations with single-nucleotide polymorphism (SNP) rs11175593 at …

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

A Franke, DPB McGovern, JC Barrett, K Wang… - Nature …, 2010 - nature.com
We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …

A genome-wide association study identifies 2 susceptibility loci for Crohn's disease in a Japanese population

K Yamazaki, J Umeno, A Takahashi, A Hirano… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Crohn's disease is an inflammatory bowel disease induced by
multiple genetic and environmental factors. Genome-wide association studies have …

Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility

A Sazonovs, CR Stevens, GR Venkataraman, K Yuan… - medRxiv, 2021 - medrxiv.org
Genome-wide association studies (GWAS) have identified hundreds of loci associated with
Crohns disease (CD), however, as with all complex diseases, deriving pathogenic …

Genome‐wide association studies in Crohn's disease: past, present and future

B Verstockt, KGC Smith, JC Lee - Clinical & translational …, 2018 - Wiley Online Library
Over the course of the past decade, genome‐wide association studies (GWAS) have
revolutionised our understanding of complex disease genetics. One of the diseases that has …