The brain is one of the most exquisite organs in the body with high metabolic demands, and
requires a tight regulation of the surrounding environment. This tight control is exerted by the …

While numerous lines of evidence point to increased levels of oxidative stress playing a
causal role in a number of neurodegenerative conditions, our current understanding of the …

The production of free radicals is inevitably associated with metabolism and other enzymatic
processes. Under physiological conditions, however, free radicals are effectively eliminated …

Stroke is one of the leading causes of mortality and morbidity, with astronomical financial
repercussions on health systems worldwide. Ischaemic stroke accounts for approximately 80 …

Alzheimer disease and cerebrovascular dementia are two common causes of dementia and,
by present diagnostic criteria, are mutually exclusive using vascular pathology as an …

Microglia‐derived inflammatory neurotoxins play a principal role in the pathogenesis of
neurodegenerative disorders including Alzheimer's disease, Parkinson's disease …

Reactive oxygen species and oxidative state are slowly gaining acceptance in having a
physiological relevance rather than just being the culprits in pathophysiological processes …

Oxidative stress has been established as a well-known pathological condition in several
neurovascular diseases. It starts with increased production of highly oxidizing free-radicals …

Alzheimer's disease (AD) and stroke are two leading causes of age‐associated dementia. A
rapidly growing body of evidence indicates that increased oxidative stress from reactive …

Molecular oxygen is essential for aerobic organisms in order to synthesize large amounts of
energy during the process of oxidative phosphorylation and it is harnessed in the form of …