Publisher Summary This chapter describes the cholinergic system in Alzheimer disease
(AD). Choline acetyltransferase (ChAT), the synthetic enzyme for acetylcholine (ACh), is …

The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …

Publisher Summary The cholinergic system of the brain has been implicated in memory
function. Evidence for this role is anatomical, physiological and pharmacological. In all …

The neurochemical pathology of Alzheimer's disease (AD) has been consistently shown to
involve cholinergic degeneration in the cerebral cortex. This together with evidence from …

The cholinergic hypothesis of Alzheimer's disease (AD) states 1. that cholinergic neurons in
the basal forebrain are severely affected in the course of disease, detectable both …

Normal aging and Alzheimer's disease are characterized by similar morphological, chemical
and behavioral changes. These include cell loss, senile plaque formation, the presence of …

The status of various cholinergic markers was compared in Alzheimer's and Parkinson's
diseases. Rather unexpectedly, similar decrements were observed in choline …

Cholinesterase (ChE) activity was measured as a possible marker of cholinergic
neurotransmission of the brain in CSF of 93 patients with probable Alzheimer's …

Publisher Summary The existence of a correlation between the loss of choline
acetyltransferase (ChAT) activity and the severity of the dementia in Alzheimer's disease …

We examined the density and the state of affinity of [3 H] hemicholinium-3 ([3 H] HC-3)
binding sites, a marker of the presynaptic high-affinity choline uptake (HACU) carrier, in 4 …