Genomics of antibiotic‐resistance prediction in Pseudomonas aeruginosa

J Jeukens, L Freschi, I Kukavica‐Ibrulj… - Annals of the New …, 2019 - Wiley Online Library
Antibiotic resistance is a worldwide health issue spreading quickly among human and
animal pathogens, as well as environmental bacteria. Misuse of antibiotics has an impact on …

Predicting antimicrobial resistance in Pseudomonas aeruginosa with machine learning‐enabled molecular diagnostics

A Khaledi, A Weimann, M Schniederjans… - EMBO molecular …, 2020 - embopress.org
Limited therapy options due to antibiotic resistance underscore the need for optimization of
current diagnostics. In some bacterial species, antimicrobial resistance can be …

Comparative genomics of a drug-resistant Pseudomonas aeruginosa panel and the challenges of antimicrobial resistance prediction from genomes

J Jeukens, I Kukavica-Ibrulj… - FEMS microbiology …, 2017 - academic.oup.com
Antimicrobial resistance (AMR) is now recognized as a global threat to human health. The
accessibility of microbial whole-genome sequencing offers an invaluable opportunity for …

A machine learning framework to predict antibiotic resistance traits and yet unknown genes underlying resistance to specific antibiotics in bacterial strains

J Sunuwar, RK Azad - Briefings in Bioinformatics, 2021 - academic.oup.com
Recently, the frequency of observing bacterial strains without known genetic components
underlying phenotypic resistance to antibiotics has increased. There are several strains of …

Antibiotic resistance in Pseudomonas aeruginosa and adaptation to complex dynamic environments

LM Sommer, HK Johansen, S Molin - Microbial genomics, 2020 - microbiologyresearch.org
Antibiotic resistance has become a serious threat to human health (WHO Antibacterial
Agents in Clinical Development: an Analysis of the Antibacterial Clinical Development …

Prediction of antibiotic resistance in Escherichia coli from large-scale pan-genome data

D Moradigaravand, M Palm, A Farewell… - PLoS computational …, 2018 - journals.plos.org
The emergence of microbial antibiotic resistance is a global health threat. In clinical settings,
the key to controlling spread of resistant strains is accurate and rapid detection. As …

A large-scale whole-genome comparison shows that experimental evolution in response to antibiotics predicts changes in naturally evolved clinical Pseudomonas …

SJT Wardell, A Rehman, LW Martin… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of acute
and chronic infections. An increasing number of isolates have mutations that make them …

A genomic data resource for predicting antimicrobial resistance from laboratory-derived antimicrobial susceptibility phenotypes

M VanOeffelen, M Nguyen, D Aytan-Aktug… - Briefings in …, 2021 - academic.oup.com
Antimicrobial resistance (AMR) is a major global health threat that affects millions of people
each year. Funding agencies worldwide and the global research community have expended …

Bioinformatics of antimicrobial resistance in the age of molecular epidemiology

AG McArthur, GD Wright - Current opinion in microbiology, 2015 - Elsevier
Highlights•Examination of antimicrobial resistance is transitioning from phenotype to
genotype.•Whole genome sequencing of pathogens will become a commonplace clinical …

Transcriptome profiling of antimicrobial resistance in Pseudomonas aeruginosa

A Khaledi, M Schniederjans, S Pohl… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Emerging resistance to antimicrobials and the lack of new antibiotic drug candidates
underscore the need for optimization of current diagnostics and therapies to diminish the …