Cooperative effects of v-myc and c-Ha-ras oncogenes on gap junctional intercellular communication and tumorigenicity in rat liver epithelial cells

T Hayashi, K Nomata, CC Chang, RJ Ruch, JE Trosko - Cancer letters, 1998 - Elsevier
The objective of this study was to isolate and partially characterize several rat liver epithelial
cell clones containing myc, ras and myc/ras oncogenes in order to study their roles in …

Homologous and heterologous Gap‐junctional intercellular communication in v‐raf‐, v‐myc‐, and v‐raf/v‐myc‐transduced rat liver epithelial cell lines

GH Kalimi, LL Hampton, JE Trosko… - Molecular …, 1992 - Wiley Online Library
We examined gap‐junctional intercellular communication (GJIC) in a series of normal and v‐
raf‐, v‐myc‐, and v‐raf/v‐myc‐transduced rat liver epithelial (RLE) cell lines using the …

Association of viral oncogene-induced changes in gap junctional intercellular communication and morphological transformation in BALB/c3T3 cells

F Katoh, JL Klein, M Bignami, H Yamasaki - Carcinogenesis, 1993 - academic.oup.com
In order to study the relationship between altered gap junctional intercellular communication
(GJIC) and induction of cell transformation by oncogenes, we transfected six viral …

Neoplastic phenotype of gap‐junctional intercellular communication–deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32

RS Rae, PP Mehta, CC Chang… - … in cooperation with …, 1998 - Wiley Online Library
Gap‐junctional intercellular communication (GJIC) is involved in cellular growth control and
is often reduced in neoplastic cells. In this study, four GJIC‐deficient rat liver epithelial cell …

Potential role of the human Ha‐ras oncogene in the inhibition of gap junctional intercellular communication

MH El‐Fouly, JE Trosko, CC Chang… - Molecular …, 1989 - Wiley Online Library
The modulation of gap junctional intercellular communication (GJIC) plays an important role
during tumor promotion. Several tumor‐promoting agents are known to inhibit this form of …

Psyllium extracts decreased neoplastic phenotypes induced by the Ha-Ras oncogene transfected into a rat liver oval cell line

Y Nakamura, JE Trosko, CC Chang, BL Upham - Cancer letters, 2004 - Elsevier
Inhibition of gap junctional intercellular communication (GJIC) by tumor promoters and
oncogenes has been implicated in the removal of initiated cells from the suppression of …

Cooperation of bcl -2 and myc in the neoplastic transformation of normal rat liver epithelial cells is related to the down-regulation of gap junction-mediated …

ND DeoCampo, MR Wilson, JE Trosko - Carcinogenesis, 2000 - academic.oup.com
The objectives of this study were to isolate several rat liver epithelial cell clones containing
the human bcl-2 and myc/bcl-2 genes in order to study their potential cooperative effect on …

Sequential changes of gap-junctional intercellular communications during multistage rat liver carcinogenesis: direct measurement of communication in vivo

VA Krutovskikh, M Oyamada, H Yamasaki - Carcinogenesis, 1991 - academic.oup.com
We have developed a simple method to measure gapjunctional intercellular communication
(GJIC), by means of microinjection/dye transfer assay, in liver slices freshly removed from …

In vitro growth inhibition of neoplastically transformed cells by non-transformed cells: requirement for gap junctional intercellular communication

CB Esinduy, CC Chang, JE Trosko, RJ Ruch - Carcinogenesis, 1995 - academic.oup.com
We examined whether the inhibition of neoplastically transformed cell growth by co-cultured
non-transformed cells involved gap junctional intercellular communication (GJIC). The …

Inhibition of gap junctional intercellular communication and malignant transformation of rat liver epithelial cells by neu oncogene

YS Jou, B Layhe, DF Matesic, CC Chang… - …, 1995 - academic.oup.com
A retrovirus containing a neu oncogene was introduced into a Fischer F344 rat liver
epithelial cell line (WB-F344) to study the effect of the expression of neu oncoprotein on gap …