Mammalian reproduction depends on the gonadotropins, follicle-stimulating hormone (FSH),
and luteinizing hormone, which are secreted by pituitary gonadotrope cells. The zinc-finger …

Single GATA-6 (G6gcko), GATA-4 (G4gcko), and double GATA-4/6 (G4/6gcko) granulosa
cell-specific knockout mice were generated to further investigate the role of GATA …

The GATA4 transcription factor is an important developmental determinant for many organs,
such as the heart, gut, and testis. Despite this pivotal role, our understanding of the …

The GATA factors are a group of transcriptional regulators that play essential roles in cell
differentiation, organ morphogenesis, and tissue-specific gene expression during …

The transforming growth factor beta (TGFB) protein family is renowned for its diverse roles in
developmental biology including reproduction. Gremlin is a member of the differential …

Synthesis of the FSH β-subunit (FSHβ) is critical for normal reproduction in mammals, and its
expression within the pituitary gonadotrope is tightly regulated by activin. Here we show that …

Transcription factor GATA4 is expressed in Sertoli and Leydig cells and is required for
proper development of the murine fetal testis. The role of GATA4 in adult testicular function …

Since the identification of steroidogenic factor 1 (SF-1 or ADBP-1) as a factor involved in the
regulation of steroidogenic enzyme gene expression, and embryological development of the …

The in vitro reconstitution of human germ-cell development provides a robust framework for
clarifying key underlying mechanisms. Here, we explored transcription factors (TFs) that …

Differential regulation of gonadotropin hormone production in the pituitary is critical for
fertility. Activin and progesterone signaling in gonadotrope cells is important for Fshb gene …