Systemic vascular pressure in vertebrates is regulated by a range of factors: one key
element of control is peripheral resistance in tissue capillary beds. Many aspects of the …

Skin plays an essential role, mediated in part by its remarkable vascular plasticity, in
adaptation to environmental stimuli. Certain vertebrates, such as amphibians, respond to …

Vascular flow through tissues is regulated via a number of homeostatic mechanisms.
Localized control of tissue blood flow, or autoregulation, is a key factor in regulating tissue …

The transcription factor HIF-1 mediates adaptive responses to hypoxia, and its activity is
negatively regulated by O 2-dependent binding of the von Hippel-Lindau (VHL) protein. In …

Low oxygen (O2) levels are a naturally occurring feature of embryonic development, adult
physiology, and diseases such as those of the cardiovascular system. Although many …

This year's Lasker Basic Medical Research Award is shared by William Kaelin, Peter
Ratcliffe, and Gregg Semenza for discovery of the pathway by which animal cells sense and …

Several molecular and cellular adaptive mechanisms to hypoxia exist within the vasculature.
Many of these processes involve oxygen sensing which is transduced into mediators of …

This review focuses on the molecular stratagems utilized by bacteria, yeast, and mammals in
their adaptation to hypoxia. Among this broad range of organisms, changes in oxygen …

Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular
metabolism to physiological adaptations facilitated by the sympathetic nervous system and …

Hypoxia signaling in the vasculature controls vascular permeability, inflammation, vascular
growth, and repair of vascular injury. In this review, we summarize recent insights in this …