Carboxylesterases are essential enzymes in the hydrolysis and detoxification of numerous
pharmaceuticals and pesticides. They are vital in mediating organophosphate toxicity and in …

A series of substituted trifluoroketones were tested as inhibitors of mammalian liver
microsomal carboxylesterase (s) hydrolyzing a variety of substrates including malathion …

Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of
xenobiotics. Because the structural and amino acid homology among esterases of different …

Purpose. Carboxylesterases are important in the detoxification of drugs, pesticides and other
xenobiotics. This study was to evaluate a series of substrates and inhibitors for …

Carboxylesterases are important enzymes responsible for the hydrolysis and metabolism of
numerous pharmaceuticals and xenobiotics. These enzymes are potently inhibited by …

Special Topic (hiCE, CES2A1) involved in the activation of CPT-11 in the intestine, but do
not affect hCE1 activity. They then discuss several strategies for in silico drug development …

Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …

Introduction: Carboxylesterases play major roles in the hydrolysis of numerous
therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety …

Carboxylesterases (CE) are ubiquitous enzymes found in both human and animal tissues
and are responsible for the metabolism of xenobiotics. This includes numerous natural …

Inhibition of intestinal carboxylesterases may allow modification of the pharmacokinetics/
pharmacodynamic profile of existing drugs by altering half-life or toxicity. Since previously …