The interaction between tumor cells and the tumor microenvironment (TME) is an important
process for the development of tumor malignancy. Modulation of paracrine cross-talk could …

Objective: Resveratrol, a safe and multitargeted natural agent, has been linked with
inhibition of survival and invasion of tumor cells. Tumor Necrosis Factor-β (TNF …

Objective: Tumor necrosis factor-beta (TNF-β), as an inflammatory mediator that has been
shown to promote tumorigenesis, induces NF-κB. Natural multi-targeted agent resveratrol in …

Background Resveratrol extracted from grape has been an ideal alternative drug in the
therapy of different cancers including colorectal cancer (CRC). Since the underlying …

Tumor resistance to therapy modalities is one of the major challenges to the eradication of
cancer cells and complete treatment. Tumor includes a wide range of cancer and non …

Resveratrol, a safe and multi-targeted agent, has been associated with suppression of
survival, proliferation and metastasis of cancer, however, the underlying mechanisms for its …

Background Increased epithelial-mesenchymal transition (EMT) and cell migration and
invasion abilities of cancer cells play important roles in the metastatic process of cancer …

Resveratrol (3, 4′, 5 trihydroxystilbene) is a naturally occurring non-flavonoid polyphenol. It
has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory …

The major cause of death in colorectal cancer (CRC) patients is metastasis. Moreover, lots of
studies have emphasized that the epithelial–mesenchymal transition (EMT) is a pivotal step …

Cancer-associated fibroblasts (CAFs) constitute a major compartment of the tumor
microenvironment. CAFs produce a variety of cytokines, growth factors and extracellular …