Sleep deprivation (SD) is a powerful antidepressant treatment that shows antidepressant
responses within hours in 40–60% of depressed patients. In more than 80% of responders …

Sleep deprivation (SD) is the most widely documented rapid-onset antidepressant therapy,
targeting the broadly defined depressive syndrome. Although SD responses are transient, its …

Growing clinical evidence in support of the efficacy and safety of sleep deprivation (SD), and
its biological mechanisms of action suggest that this technique can now be included among …

Objective: To provide a quantitative meta-analysis of the antidepressant effects of sleep
deprivation to complement qualitative reviews addressing response rates. Data Sources …

Therapeutic sleep deprivation (SD) is a rapid acting treatment for major depressive disorder
(MDD). Within hours, SD leads to a dramatic decrease in depressive symptoms in 50–60 …

The assumption that sleep dysregulation is more than a mere epiphenomenon of
depression is based on several observations: sleep disturbances are strongly associated …

Manipulations of the sleep-wake cycle, whether of duration (total or partial sleep deprivation
[SD]) or timing (partial SD, phase advance), have profound and rapid effects on depressed …

Total sleep deprivation (TSD) for one whole night improves depressive symptoms in 40–
60% of treatments. The degree of clinical change spans a continuum from complete …

Objective To systematically review evidence on the efficacy and safety of sleep deprivation
(SD) as a treatment option for patients with unipolar or bipolar depression. Methods A …

Depression is increasingly prevalent in Western countries. It has severe consequences and
is associated with increased rates of disability, morbidity, and mortality. Despite numerous …