A Novel Risk Locus at 6p21. 3 for Epstein–Barr Virus-Positive Hodgkin Lymphoma

M Delahaye-Sourdeix, KY Urayama, V Gaborieau… - … Biomarkers & Prevention, 2015 - AACR
Background: A proportion of the genetic variants involved in susceptibility to Hodgkin
lymphoma differ by the tumor's Epstein–Barr virus (EBV) status, particularly within the MHC …

Genome-wide association study of classical Hodgkin lymphoma and Epstein–Barr virus status–defined subgroups

KY Urayama, RF Jarrett, H Hjalgrim… - Journal of the …, 2012 - academic.oup.com
Background Accumulating evidence suggests that risk factors for classical Hodgkin
lymphoma (cHL) differ by tumor Epstein–Barr virus (EBV) status. This potential etiological …

Modeling HLA associations with EBV‐positive and‐negative H odgkin lymphoma suggests distinct mechanisms in disease pathogenesis

PCD Johnson, KA McAulay… - … Journal of Cancer, 2015 - Wiley Online Library
HLA genotyping and genome wide association studies provide strong evidence for
associations between Human Leukocyte Antigen (HLA) alleles and classical Hodgkin …

Candidate gene association studies and risk of Hodgkin lymphoma: a systematic review and meta‐analysis

A Sud, K Hemminki, RS Houlston - Hematological oncology, 2017 - Wiley Online Library
To evaluate the contribution of association studies of candidate polymorphisms to inherited
predisposition to Hodgkin lymphoma (HL), we conducted a systematic review and meta …

[HTML][HTML] Variation at 3p24. 1 and 6q23. 3 influences the risk of Hodgkin's lymphoma

M Frampton, MI da Silva Filho, P Broderick… - Nature …, 2013 - nature.com
In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's
lymphoma (HL) have identified susceptibility loci for HL at 2p16. 1, 8q24. 21 and 10p14. In …

[HTML][HTML] HLA Allele E*01:01 Is Associated with a Reduced Risk of EBV-Related Classical Hodgkin Lymphoma Independently of HLA-A*01/*02

P Martín, I Krsnik, B Navarro, M Provencio, JF García… - PLoS …, 2015 - journals.plos.org
Background An inefficient immune response against Epstein-Barr virus (EBV) infection is
related to the pathogenesis of a subgroup of classical Hodgkin lymphomas (cHL). Some …

Genetic associations in classical hodgkin lymphoma: a systematic review and insights into susceptibility mechanisms

K Kushekhar, A van den Berg, I Nolte, B Hepkema… - … Biomarkers & Prevention, 2014 - AACR
Both targeted and genome-wide studies have revealed genetic associations for
susceptibility, prognosis, and treatment-induced secondary malignancies and toxicities in …

[HTML][HTML] HLA expression and HLA type associations in relation to EBV status in Hispanic Hodgkin lymphoma patients

LB Fletcher, RN Veenstra, EY Loo, AE Hwang… - PLoS …, 2017 - journals.plos.org
A proportion of classical Hodgkin lymphomas harbor the Epstein Barr virus (EBV). We
previously demonstrated that associations between Human Leukocyte Antigen (HLA) alleles …

The Human Leukocyte Antigen Class I Region Is Associated with EBV-Positive Hodgkin's Lymphoma: HLA-A and HLA Complex Group 9 Are Putative Candidate …

M Niens, A Van Den Berg, A Diepstra, IM Nolte… - … Biomarkers & Prevention, 2006 - AACR
Various studies have indicated that the human leukocyte antigen (HLA) region is associated
with Hodgkin's lymphoma. We recently showed a specific association of the HLA class I …

Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts

H Ghesquières, MJ Maurer, O Casasnovas, SM Ansell… - Cytokine, 2013 - Elsevier
Background Cytokines are important immune mediators of classical Hodgkin lymphoma
(CHL) pathogenesis, and circulating levels at diagnosis may help predict prognosis …