Second generation G-quadruplex stabilizing trimethine cyanines
EA Owens, HT Huynh, EM Stroeva… - Bioconjugate …, 2019 - ACS Publications
G-Quadruplex DNA has been recognized as a highly appealing target for the development
of new selective chemotherapeutics, which could result in markedly reduced toxicity toward …
of new selective chemotherapeutics, which could result in markedly reduced toxicity toward …
Halogenated pentamethine cyanine dyes exhibiting high fidelity for G-quadruplex DNA
R Nanjunda, EA Owens, L Mickelson… - Bioorganic & medicinal …, 2012 - Elsevier
Design and optimization of quadruplex-specific small molecules is developing into an
attractive strategy for anti-cancer therapeutics with some promising candidates in clinical …
attractive strategy for anti-cancer therapeutics with some promising candidates in clinical …
Selective G-quadruplex DNA recognition by a new class of designed cyanines
A variety of cyanines provide versatile and sensitive agents acting as DNA stains and
sensors and have been structurally modified to bind in the DNA minor groove in a sequence …
sensors and have been structurally modified to bind in the DNA minor groove in a sequence …
Simultaneous binding of hybrid molecules constructed with dual DNA-binding components to a G-quadruplex and its proximal duplex
S Asamitsu, S Asamitsu - … Ligands: Understanding the Function of Non …, 2020 - Springer
A G-quadruplex (quadruplex) is a nucleic acid secondary structure adopted by guanine-rich
sequences and is considered to be relevant to various pharmacological and biological …
sequences and is considered to be relevant to various pharmacological and biological …
Bisaryldiketene derivatives: A new class of selective ligands for c-myc G-quadruplex DNA
D Peng, JH Tan, SB Chen, TM Ou, LQ Gu… - Bioorganic & medicinal …, 2010 - Elsevier
A series of bisaryldiketene derivatives were designed and synthesized as a new class of
specific G-quadruplex ligands. The ligand–quadruplex interactions were further evaluated …
specific G-quadruplex ligands. The ligand–quadruplex interactions were further evaluated …
A benzimidazopyridoquinoxaline as promising scaffold for G-quadruplex DNA targeting
A Zanzoul, Y Ramli, EM Essassi, G Pratviel - Medicinal Chemistry …, 2014 - Springer
In the search for new molecular scaffolds for G-quadruplex DNA targeting, we prepared a
pentacyclic, crescent-shaped, benzimidazopyridoquinoxaline derivative, which proved to …
pentacyclic, crescent-shaped, benzimidazopyridoquinoxaline derivative, which proved to …
Functional evaluation of novel chromon derivative compounds for recognition of G-quadruplex structure
Currently, G-quadruplex structure targeting strategies are considered as a promising
anticancer approach. The purpose of this research is to expand the options for G-quadruplex …
anticancer approach. The purpose of this research is to expand the options for G-quadruplex …
Deciphering the binding insights of novel disubstituted anthraquinone derivatives with G‐quadruplex DNA to exhibit selective cancer cell cytotoxicity
Anthraquinone‐based compounds are well‐known as duplex DNA as well as G‐quadruplex
DNA binders. Implications of various anthraquinone derivatives for specific recognition of G …
DNA binders. Implications of various anthraquinone derivatives for specific recognition of G …
Ligand design to acquire specificity to intended G‐quadruplex structures
S Asamitsu, T Bando… - Chemistry–A European …, 2019 - Wiley Online Library
AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …
sequences, and is considered to be relevant in various pharmacological and biological …
The role of positive charges on G-quadruplex binding small molecules: Learning from bisaryldiketene derivatives
SB Chen, QX Shi, D Peng, SY Huang, TM Ou… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Background G-quadruplexes are promising therapeutic targets for small molecules. In
general, the introduction of steady positive charges through the in situ alkylation of nitrogen …
general, the introduction of steady positive charges through the in situ alkylation of nitrogen …