[HTML][HTML] Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa
K Do Rhee, A Ruiz, JL Duncan… - … & visual science, 2007 - iovs.arvojournals.org
purpose. To characterize molecular and cellular changes induced by sustained expression
of ciliary neurotrophic factor (CNTF) in the rds mutant mouse retina. methods. Recombinant …
of ciliary neurotrophic factor (CNTF) in the rds mutant mouse retina. methods. Recombinant …
CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Müller glial cells
KD Rhee, S Nusinowitz, K Chao, F Yu… - Proceedings of the …, 2013 - National Acad Sciences
Ciliary neurotrophic factor (CNTF) acts as a potent neuroprotective agent in multiple retinal
degeneration animal models. Recently, CNTF has been evaluated in clinical trials for the …
degeneration animal models. Recently, CNTF has been evaluated in clinical trials for the …
Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation
D Bok, D Yasumura, MT Matthes, A Ruiz… - Experimental eye …, 2002 - Elsevier
Past studies have shown that acute administration of ciliary neurotrophic factor (CNTF) can
prolong the survival of retinal photoreceptor cells that have undergone phototoxic injury or …
prolong the survival of retinal photoreceptor cells that have undergone phototoxic injury or …
[HTML][HTML] Ciliary neurotrophic factor induces genes associated with inflammation and gliosis in the retina: a gene profiling study of flow-sorted, Müller cells
Background Ciliary neurotrophic factor (CNTF), a member of the interleukin-6 cytokine
family, has been implicated in the development, differentiation and survival of retinal …
family, has been implicated in the development, differentiation and survival of retinal …
[HTML][HTML] Expression of cytokine signal transduction components in the postnatal mouse retina
K Do Rhee, XJ Yang - Molecular vision, 2003 - ncbi.nlm.nih.gov
Purpose: Members of the ciliary neurotrophic factor (CNTF) family of cytokines have been
shown to influence neuronal differentiation during retinal development and enhance cell …
shown to influence neuronal differentiation during retinal development and enhance cell …
Intraocular Gene Transfer of Ciliary Neurotrophic Factor Prevents Death and Increases Responsiveness of Rod Photoreceptors in theretinal degeneration slow mouse
M Cayouette, D Behn, M Sendtner… - Journal of …, 1998 - Soc Neuroscience
Several mutations causing both photoreceptor degeneration and malfunction have been
identified in humans and animals. Although intraocular injection of trophic factors has been …
identified in humans and animals. Although intraocular injection of trophic factors has been …
Ciliary neurotrophic factor protects rat retina cells in vitro and in vivo via PI3 kinase
K Ikeda, T Tatsuno, H Noguchi… - Current eye research, 2004 - Taylor & Francis
Purpose. Neurotrophic factors and neurotrophins are well-known to have neuroprotective
efficacy against retinal injury. The aim of this experiment is to investigate the signal …
efficacy against retinal injury. The aim of this experiment is to investigate the signal …
Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina
WA Beltran, R Wen, GM Acland, GD Aguirre - Experimental eye research, 2007 - Elsevier
Ciliary neurotrophic factor (CNTF) rescues photoreceptors in several animal models of
retinal degeneration and is currently being evaluated as a potential treatment for retinitis …
retinal degeneration and is currently being evaluated as a potential treatment for retinitis …
Ciliary neurotrophic factor induces glial fibrillary acidic protein in retinal Müller cells through the JAK/STAT signal transduction pathway
Y Wang, SB Smith, JM Ogilvie, DJ McCool… - Current eye …, 2002 - Taylor & Francis
Purpose. Intravitreal injection of ciliary neurotrophic factor (CNTF) is known to induce glial
intermediate filament protein (GFAP) expression in retinal Müller cells. Because CNTF …
intermediate filament protein (GFAP) expression in retinal Müller cells. Because CNTF …
Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal …
FC Schlichtenbrede, A MacNeil, JWB Bainbridge… - Gene therapy, 2003 - nature.com
Intraocular delivery of a variety of neurotrophic factors has been widely investigated as a
potential treatment for retinal dystrophy (RD). The most commonly studied factor, ciliary …
potential treatment for retinal dystrophy (RD). The most commonly studied factor, ciliary …