Most neurological diseases have a multifactorial nature and the number of molecular
mechanisms discovered as underpinning these diseases is continuously evolving. The old …

Dopamine is a key regulator in the CNS, contributing importantly to functions of arousal and
attention, initiation of movement, perception, motivation and emotion. Its imbalance has …

Our current understanding of the relationship between the dopaminergic system and human
brain disorders is based on two fundamental discoveries: dopamine-replacement therapy …

As sites of action for drugs used to treat schizophrenia and Parkinson's disease, dopamine
receptors are among the most validated drug targets for neuropsychiatric disorders …

Other chapters in this volume document the explosive recent advances in the genetic,
neuroanatomical, and molecular pharmacological understanding of both the traditional and …

There has been an extraordinary recent accumulation of information concerning the
neurobiology and neuropharmacology of dopamine (DA) receptors in the mammalian …

Dopamine neurotransmission is traditionally accepted as occurring through the five
dopamine receptors that transduce its signal. Recent evidence has demonstrated that the …

G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …

The dopaminergic system integrated by cell groups distributed in several brain regions
exerts a modulatory role in brain. Particularly important for this task are the mesencephalic …

Whereas biochemical and pharmacological studies indicated that there were two
subclasses of dopamine receptor (D 1, D 2) the application of molecular biology techniques …