Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP …

SM Raefsky, R Furman, G Milne, E Pollock… - Neurobiology of …, 2018 - Elsevier
Alzheimer's disease (AD) involves progressive deposition of amyloid β-peptide (Aβ),
synapse loss, and neuronal death, which occur in brain regions critical for learning and …

Deuterium‐reinforced polyunsaturated fatty acids improve cognition in a mouse model of sporadic Alzheimer's disease

A Elharram, NM Czegledy, M Golod, GL Milne… - The FEBS …, 2017 - Wiley Online Library
Oxidative damage resulting from increased lipid peroxidation (LPO) is considered an
important factor in the development of late onset/age‐related Alzheimer's disease (AD) …

Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease

M Lebbadi, C Julien, A Phivilay… - Journal of …, 2011 - content.iospress.com
Dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) reduces amyloid-β
(Aβ) and tau pathology and improves cognitive performance in animal models of Alzheimer's …

A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model

GP Lim, F Calon, T Morihara, F Yang… - Journal of …, 2005 - Soc Neuroscience
Epidemiological studies suggest that increased intake of the omega-3 (n-3) polyunsaturated
fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of …

[HTML][HTML] Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice

KE Hopperton, MO Trépanier, V Giuliano… - Journal of …, 2016 - Springer
Background Neuroinflammation is a proposed mechanism by which Alzheimer's disease
(AD) pathology potentiates neuronal death and cognitive decline. Consumption of omega-3 …

Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization

E Teng, K Taylor, T Bilousova, D Weiland, T Pham… - Neurobiology of …, 2015 - Elsevier
Increased dietary consumption of docosahexaenoic acid (DHA) is associated with
decreased risk for Alzheimer's disease (AD). These effects have been postulated to arise …

A specific multi-nutrient diet reduces Alzheimer-like pathology in young adult AβPP swe/PS1 dE9 mice

LM Broersen, AAM Kuipers, M Balvers… - Journal of …, 2013 - content.iospress.com
Diet is an important lifestyle factor implicated in the etiology of Alzheimer's disease (AD), but
so far it is not fully elucidated to which nutrients the suggested protective effect of diet can be …

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

M Oksman, H Iivonen, E Hogyes, Z Amtul, B Penke… - Neurobiology of …, 2006 - Elsevier
The present study assessed the influence of dietary lipids on accumulation of amyloid beta-
peptide (Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and …

DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

CR Hooijmans, C Van der Zee, PJ Dederen… - Neurobiology of …, 2009 - Elsevier
Cholesterol and docosahexenoic acid (DHA) may affect degenerative processes in
Alzheimer's Disease (AD) by influencing Aβ metabolism indirectly via the vasculature. We …

Enriched endogenous n-3 polyunsaturated fatty acids alleviate cognitive and behavioral deficits in a mice model of Alzheimer's disease

K Wu, X Gao, B Shi, S Chen, X Zhou, Z Li, Y Gan, L Cui… - Neuroscience, 2016 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accompanied by
memory deficits and neuropsychiatric dysfunction. Omega-3 polyunsaturated fatty acids (n-3 …