Palmitoylethanolamide protects against the amyloid-β25-35-induced learning and memory impairment in mice, an experimental model of Alzheimer disease
G D'agostino, R Russo, C Avagliano… - …, 2012 - nature.com
Alzheimer disease (AD) is the most common form of neurodegenerative dementia. Amyloid-
β deposition, neurofibrillary tangle formation, and neuro-inflammation are the major …
β deposition, neurofibrillary tangle formation, and neuro-inflammation are the major …
[HTML][HTML] The hydroxylated form of docosahexaenoic acid (DHA-H) modifies the brain lipid composition in a model of Alzheimer's disease, improving behavioral motor …
RJ Mohaibes, MA Fiol-deRoque, M Torres… - … et Biophysica Acta (BBA …, 2017 - Elsevier
We have compared the effect of the commonly used ω-3 fatty acid, docosahexaenoic acid
ethyl ester (DHA-EE), and of its 2-hydroxylated DHA form (DHA-H), on brain lipid …
ethyl ester (DHA-EE), and of its 2-hydroxylated DHA form (DHA-H), on brain lipid …
Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms
S Sarroca, A Gatius, E Rodríguez-Farré… - The Journal of nutritional …, 2021 - Elsevier
Cumulative evidence indicates that excessive consumption of calories from saturated fat
contributes to the development of Alzheimer's disease (AD). Here, we assess the triggering …
contributes to the development of Alzheimer's disease (AD). Here, we assess the triggering …
Dietary fatty acids and the aging brain
GM Cole, QL Ma, SA Frautschy - Nutrition reviews, 2010 - academic.oup.com
Aging contributes to physiological decline and vulnerability to disease. In the brain, even
with minimal neuronal loss, aging increases oxidative damage, inflammation, demyelination …
with minimal neuronal loss, aging increases oxidative damage, inflammation, demyelination …
Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions
Alzheimer's disease (AD) and cardiovascular disease (CVD) are syndromes of aging that
share analogous lesions and risk factors, involving lipoproteins, oxidative damage and …
share analogous lesions and risk factors, involving lipoproteins, oxidative damage and …
Effects of docosahexaenoic acid and its peroxidation product on amyloid-β peptide-stimulated microglia
Growing evidence suggests that docosahexaenoic acid (DHA) exerts neuroprotective
effects, although the mechanism (s) underlying these beneficial effects are not fully …
effects, although the mechanism (s) underlying these beneficial effects are not fully …
The essential role of lipids in Alzheimer's disease
S Florent-Bechard, C Desbene, P Garcia, A Allouche… - Biochimie, 2009 - Elsevier
In the absence of efficient diagnostic and therapeutic tools, Alzheimer's disease (AD) is a
major public health concern due to longer life expectancy in the Western countries. Although …
major public health concern due to longer life expectancy in the Western countries. Although …
Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid‐β oligomers
S Florent, C Malaplate‐Armand… - Journal of …, 2006 - Wiley Online Library
A growing body of evidence supports the notion that soluble oligomers of amyloid‐β (Aβ)
peptide interact with the neuronal plasma membrane, leading to cell injury and inducing …
peptide interact with the neuronal plasma membrane, leading to cell injury and inducing …
Comparative study of different polar groups of EPA‐enriched phospholipids on ameliorating memory loss and cognitive deficiency in aged SAMP8 mice
Scope Recent studies have shown that omega‐3 PUFAs enriched phospholipids (n‐3 PUFA‐
PLs) have beneficial effects on memory and cognition. However, most reports only attribute …
PLs) have beneficial effects on memory and cognition. However, most reports only attribute …
The relationship of omega 3 polyunsaturated fatty acids in red blood cell membranes with cognitive function and brain structure: A review focussed on Alzheimer's …
C Hooper, P De Souto Barreto, M Pahor… - The journal of …, 2018 - Springer
Significant research attention has focussed on the identification of nutraceutical agents for
the prevention of cognitive decline as a natural means of cognitive preservation in the …
the prevention of cognitive decline as a natural means of cognitive preservation in the …