Palmitoylethanolamide protects against the amyloid-β25-35-induced learning and memory impairment in mice, an experimental model of Alzheimer disease

G D'agostino, R Russo, C Avagliano… - …, 2012 - nature.com
Alzheimer disease (AD) is the most common form of neurodegenerative dementia. Amyloid-
β deposition, neurofibrillary tangle formation, and neuro-inflammation are the major …

[HTML][HTML] The hydroxylated form of docosahexaenoic acid (DHA-H) modifies the brain lipid composition in a model of Alzheimer's disease, improving behavioral motor …

RJ Mohaibes, MA Fiol-deRoque, M Torres… - … et Biophysica Acta (BBA …, 2017 - Elsevier
We have compared the effect of the commonly used ω-3 fatty acid, docosahexaenoic acid
ethyl ester (DHA-EE), and of its 2-hydroxylated DHA form (DHA-H), on brain lipid …

Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms

S Sarroca, A Gatius, E Rodríguez-Farré… - The Journal of nutritional …, 2021 - Elsevier
Cumulative evidence indicates that excessive consumption of calories from saturated fat
contributes to the development of Alzheimer's disease (AD). Here, we assess the triggering …

Dietary fatty acids and the aging brain

GM Cole, QL Ma, SA Frautschy - Nutrition reviews, 2010 - academic.oup.com
Aging contributes to physiological decline and vulnerability to disease. In the brain, even
with minimal neuronal loss, aging increases oxidative damage, inflammation, demyelination …

Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions

GM Cole, GP Lim, F Yang, B Teter, A Begum, Q Ma… - Neurobiology of …, 2005 - Elsevier
Alzheimer's disease (AD) and cardiovascular disease (CVD) are syndromes of aging that
share analogous lesions and risk factors, involving lipoproteins, oxidative damage and …

Effects of docosahexaenoic acid and its peroxidation product on amyloid-β peptide-stimulated microglia

X Geng, B Yang, R Li, T Teng, MJ Ladu, GY Sun… - Molecular …, 2020 - Springer
Growing evidence suggests that docosahexaenoic acid (DHA) exerts neuroprotective
effects, although the mechanism (s) underlying these beneficial effects are not fully …

The essential role of lipids in Alzheimer's disease

S Florent-Bechard, C Desbene, P Garcia, A Allouche… - Biochimie, 2009 - Elsevier
In the absence of efficient diagnostic and therapeutic tools, Alzheimer's disease (AD) is a
major public health concern due to longer life expectancy in the Western countries. Although …

Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid‐β oligomers

S Florent, C Malaplate‐Armand… - Journal of …, 2006 - Wiley Online Library
A growing body of evidence supports the notion that soluble oligomers of amyloid‐β (Aβ)
peptide interact with the neuronal plasma membrane, leading to cell injury and inducing …

Comparative study of different polar groups of EPA‐enriched phospholipids on ameliorating memory loss and cognitive deficiency in aged SAMP8 mice

M Zhou, H Che, J Huang, T Zhang, J Xu… - Molecular nutrition & …, 2018 - Wiley Online Library
Scope Recent studies have shown that omega‐3 PUFAs enriched phospholipids (n‐3 PUFA‐
PLs) have beneficial effects on memory and cognition. However, most reports only attribute …

The relationship of omega 3 polyunsaturated fatty acids in red blood cell membranes with cognitive function and brain structure: A review focussed on Alzheimer's …

C Hooper, P De Souto Barreto, M Pahor… - The journal of …, 2018 - Springer
Significant research attention has focussed on the identification of nutraceutical agents for
the prevention of cognitive decline as a natural means of cognitive preservation in the …