[HTML][HTML] Engineering of regulatory T cells by means of mRNA electroporation in a GMP-compliant manner

I Janssens, DC Davó, J Van den Bos, H De Reu… - Cytotherapy, 2022 - Elsevier
Regulatory T cells (Tregs) are crucial in inducing and maintaining tolerance. This unique
capacity of Tregs, in combination with proof-of-principle in preclinical studies, highlights the …

Regulatory T cells for the induction of transplantation tolerance

W Que, XK Li - T Regulatory Cells in Human Health and Diseases, 2021 - Springer
Organ transplantation is the optimal treatment for terminal and irreversible organ failure.
Achieving transplantation tolerance has long been the ultimate goal in the field of …

A rapamycin-based GMP-compatible process for the isolation and expansion of regulatory T cells for clinical trials

H Fraser, N Safinia, N Grageda, S Thirkell… - … therapy Methods & …, 2018 - cell.com
The concept of regulatory T cell (Treg)-based immunotherapy has enormous potential for
facilitating tolerance in autoimmunity and transplantation. Clinical translation of Treg cell …

Methods to manufacture regulatory T cells for cell therapy

KN MacDonald, JM Piret… - Clinical & Experimental …, 2019 - academic.oup.com
Regulatory T cell (Treg) therapy has shown promise in early clinical trials for treating graft-
versus-host disease, transplant rejection and autoimmune disorders. A challenge has been …

Regulatory T cells for tolerance

K Kawai, M Uchiyama, J Hester, K Wood, F Issa - Human immunology, 2018 - Elsevier
Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant
promise in the quest for transplantation tolerance. Progress has now reached a critical …

Therapeutic potential of gene-modified regulatory T cells: from bench to bedside

WJ Chae, ALM Bothwell - Frontiers in Immunology, 2018 - frontiersin.org
Regulatory T cells (Tregs) are an important subset of adaptive immune cells and control
immune reactions for maintaining homeostasis. Tregs are generated upon their encounter …

Manufacturing regulatory T cells for adoptive cell therapy in immune diseases: A critical appraisal

K Abhishek, M Nidhi, S Chandran, SS Shevkoplyas… - Clinical …, 2023 - Elsevier
Regulatory T cells (Tregs) are a unique subset of lymphocytes that play a vital role in
regulating the immune system by suppressing unwanted immune responses and thus …

Regulatory T cells: customizing for the clinic

X Wang, L Lu, S Jiang - Science translational medicine, 2011 - science.org
Immune-suppressive cellular immunotherapy requires large numbers of antigen-specific
regulatory T cells (Treg cells), lymphocytes that suppress certain immune responses …

Regulatory T cells: serious contenders in the promise for immunological tolerance in transplantation

N Safinia, C Scotta, T Vaikunthanathan… - Frontiers in …, 2015 - frontiersin.org
Regulatory T cells (Tregs) play an important role in immunoregulation and have been shown
in animal models to promote transplantation tolerance and curb autoimmunity following their …

Harnessing regulatory T cells to establish immune tolerance

P Ho, E Cahir-McFarland, JD Fontenot… - Science Translational …, 2024 - science.org
Engineered regulatory T (Treg) cells have emerged as precision therapeutics aimed at
inducing immune tolerance while reducing the risks associated with generalized …