The inflammatory response to cardiac surgery and CPB involves interactions between many
signaling molecules (DAMP's, chemokines, cytokines and non-cytokine inflammatory …

Objectives: The objectives of this review are to discuss the pathophysiology of the pro-
inflammatory response to the cardiopulmonary bypass circuit, the impact of ischemia …

The systemic inflammatory response to cardiac surgery is common, and resultant
impairment of multiple organ function is generally mild or subclinical due to physiological …

Paediatric cardiac surgery often requires cardiopulmonary bypass (CPB) during the surgical
intervention. CPB is known to elicit a systemic inflammatory response with activation of the …

BACKGROUND: Cardiopulmonary bypass (CPB) induces a systemic inflammatory
response. The magnitude and consequences in infants remain unclear. We assessed the …

Despite many advances since Gibbon's first cardiopulmonary bypass (CPB) in 1953, end-
organ damage and neurologic dysfunction remain a challenge in the management of …

Background Cardiac surgery in infants results in a profound inflammatory response
secondary to cardiopulmonary bypass (CPB) and the need for blood products. It is not clear …

Inflammation in cardiac surgical patients is produced by complex humoral and cellular
interactions with numerous pathways including activation, generation, or expression of …

Cardiopulmonary bypass is known to trigger a global inflammatory response. Age-
dependent differences in the inflammatory response, the increased susceptibility to injury of …

Background There are few detailed descriptions of the inflammatory response to cardiac
surgery with cardiopulmonary bypass (CPB) in children beyond 24 h postoperatively. This is …