Activation of SGK1. 1 Upregulates the M-current in the Presence of Epilepsy Mutations
E Martin-Batista, RW Manville… - Frontiers in Molecular …, 2021 - frontiersin.org
In the central nervous system, the M-current plays a critical role in regulating subthreshold
electrical excitability of neurons, determining their firing properties and responsiveness to …
electrical excitability of neurons, determining their firing properties and responsiveness to …
The neuronal serum-and glucocorticoid-regulated kinase 1.1 reduces neuronal excitability and protects against seizures through upregulation of the M-current
P Miranda, A Cadaveira-Mosquera… - Journal of …, 2013 - Soc Neuroscience
The M-current formed by tetramerization of Kv7. 2 and Kv7. 3 subunits is a neuronal voltage-
gated K+ conductance that controls resting membrane potential and cell excitability. In …
gated K+ conductance that controls resting membrane potential and cell excitability. In …
Mutations in Kv7. 5 Channels Associated with Intellectual Disability or Epileptic Encephalopathy
The M-current is a slowly activating and deactivating K+ current that plays a crucial role in
regulating neuronal excitability by impeding repetitive action potential firing during sustained …
regulating neuronal excitability by impeding repetitive action potential firing during sustained …
A possible link between KCNQ2‐ and STXBP1‐related encephalopathies: STXBP1 reduces the inhibitory impact of syntaxin‐1A on M current
J Devaux, S Dhifallah, M De Maria, G Stuart‐Lopez… - …, 2017 - Wiley Online Library
Objective Kv7 channels mediate the voltage‐gated M‐type potassium current. Reduction of
M current due to KCNQ 2 mutations causes early onset epileptic encephalopathies (EOEEs) …
M current due to KCNQ 2 mutations causes early onset epileptic encephalopathies (EOEEs) …
The Voltage-Sensor S4 Rises to the Occasion in KCNQ2 Channel Activation
CE Stafstrom - Epilepsy Currents, 2023 - journals.sagepub.com
Distinctive Mechanisms of Epilepsy-Causing Mutants Discovered by Measuring S4
Movement in KCNQ2 Channels Edmond MA, Hinojo-Perez A, Wu X, Perez Rodriguez ME …
Movement in KCNQ2 Channels Edmond MA, Hinojo-Perez A, Wu X, Perez Rodriguez ME …
Attenuating M‐current suppression in vivo by a mutant Kcnq2 gene knock‐in reduces seizure burden and prevents status epilepticus–induced neuronal death and …
DL Greene, A Kosenko, N Hoshi - Epilepsia, 2018 - Wiley Online Library
Objectives The M‐current is a low‐threshold voltage‐gated potassium current generated by
Kv7 subunits that regulates neural excitation. It is important to note that M‐current …
Kv7 subunits that regulates neural excitation. It is important to note that M‐current …
The role of Kv7. 2 in neurodevelopment: insights and gaps in our understanding
N Dirkx, F Miceli, M Taglialatela… - Frontiers in …, 2020 - frontiersin.org
Kv7. 2 subunits encoded by the KCNQ2 gene constitute a critical molecular component of
the M-current, a subthreshold voltage-gated potassium current controlling neuronal …
the M-current, a subthreshold voltage-gated potassium current controlling neuronal …
A Novel Kv7.3 Variant in the Voltage-Sensing S4 Segment in a Family With Benign Neonatal Epilepsy: Functional Characterization and in vitro Rescue by β …
F Miceli, L Carotenuto, V Barrese… - Frontiers in …, 2020 - frontiersin.org
Pathogenic variants in KCNQ2 and KCNQ3, paralogous genes encoding Kv7. 2 and Kv7. 3
voltage-gated K+ channel subunits, are responsible for early− onset developmental/epileptic …
voltage-gated K+ channel subunits, are responsible for early− onset developmental/epileptic …
K+ M‐Current Regulates the Transition to Seizures in Immature and Adult Hippocampus
C Qiu, BN Johnson, MK Tallent - Epilepsia, 2007 - Wiley Online Library
Purpose: Loss‐of‐function mutations in Kv7. 2 or Kv7. 3 K+ channel subunits underlies the
neonatal epilepsy benign familial neonatal convulsions (BFNC). These two subunits interact …
neonatal epilepsy benign familial neonatal convulsions (BFNC). These two subunits interact …
Novel loss-of-function mutations in KV7. 2, and their possible involvement in epilepsy
KV 7.2 potassium channels play a key role in controlling excitability of neurons in the central
nervous system by contributing to shaping of the action potential. Therefore, mutations of the …
nervous system by contributing to shaping of the action potential. Therefore, mutations of the …