BACKGROUND Prostate cancer linkage studies have been used to localize rare and
presumably highly penetrant cancer susceptibility genes. Underlying genetic heterogeneity …

Background Two prostate cancer genome-wide scans in populations of European ancestry
identified several genetic variants that are strongly associated with prostate cancer risk. The …

In this study, we review a variety of genetic polymorphisms that may have an etiologic role in
prostate cancer. We include associations identified in molecular epidemiology studies and …

Background Genome‐wide association studies have identified over 100 single‐nucleotide
polymorphisms (SNPs) associated with prostate cancer (PrCa), and polygenic risk scores …

Purpose: Fifteen independent genetic variants have been implicated in prostate cancer risk
by recent genome-wide association studies. However, their association with …

BACKGROUND A strong cumulative effect of five genetic variants and family history on
prostate cancer risk was recently reported in a Swedish population (CAPS). We carried out …

Background. Family history of prostate cancer is a risk factor for prostate cancer occurrence.
Differently from other neoplasms no major predisposing gene has been identified. Material …

The search for susceptibility loci in hereditary prostate cancer (HPC) has proven challenging
due to genetic and disease heterogeneity. Multiple risk loci have been identified to date …

Prostate cancer (PCa) is the most common solid organ malignancy diagnosed in American
men and the second leading cause of cancer-related mortality. In the United States, 192,000 …

To identify rare variants associated with prostate cancer susceptibility and better
characterize the mechanisms and cumulative disease risk associated with common risk …