Role of caspase-3-mediated apoptosis in chronic caspase-3-cleaved tau accumulation and blood–brain barrier damage in the corpus callosum after traumatic brain …

OY Glushakova, AO Glushakov… - Journal of …, 2018 - liebertpub.com
Traumatic brain injury (TBI) may be a significant risk factor for development of
neurodegenerative disorders such as chronic traumatic encephalopathy (CTE), post …

Increased amyloid precursor protein and tau expression manifests as key secondary cell death in chronic traumatic brain injury

SA Acosta, N Tajiri, PR Sanberg… - Journal of cellular …, 2017 - Wiley Online Library
In testing the hypothesis of Alzheimer's disease (AD)‐like pathology in late stage traumatic
brain injury (TBI), we evaluated AD pathological markers in late stage TBI model. Sprague …

Chronic upregulation of cleaved-caspase-3 associated with chronic myelin pathology and microvascular reorganization in the thalamus after traumatic brain injury in …

AO Glushakov, OY Glushakova, TY Korol… - International journal of …, 2018 - mdpi.com
Traumatic brain injury (TBI) is associated with long-term disabilities and devastating chronic
neurological complications including problems with cognition, motor function, sensory …

Temporal profile and cell subtype distribution of activated caspase‐3 following experimental traumatic brain injury

R Beer, G Franz, A Srinivasan, RL Hayes… - Journal of …, 2000 - Wiley Online Library
This study investigated the temporal expression and cell subtype distribution of activated
caspase‐3 following cortical impact‐induced traumatic brain injury in rats. The animals were …

Cleaved-tau: a biomarker of neuronal damage after traumatic brain injury

SP Gabbita, SW Scheff, RM Menard… - Journal of …, 2005 - liebertpub.com
Previous studies from our laboratory indicate that traumatic brain injury (TBI) in humans
results in proteolysis of neuronally-localized, intracellular microtubule associated protein …

Novel mouse tauopathy model for repetitive mild traumatic brain injury: evaluation of long-term effects on cognition and biomarker levels after therapeutic inhibition of …

R Rubenstein, DR Sharma, B Chang, N Oumata… - Frontiers in …, 2019 - frontiersin.org
Traumatic brain injury (TBI) is a risk factor for a group of neurodegenerative diseases termed
tauopathies, which includes Alzheimer's disease and chronic traumatic encephalopathy …

Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review …

A Kahriman, J Bouley, TW Smith, DA Bosco… - Acta Neuropathologica …, 2021 - Springer
Traumatic brain injury (TBI) constitutes one of the strongest environmental risk factors for
several progressive neurodegenerative disorders of cognitive impairment and dementia that …

Temporal and spatial profile of caspase 8 expression and proteolysis after experimental traumatic brain injury

R Beer, G Franz, S Krajewski, BR Pike… - Journal of …, 2001 - Wiley Online Library
Recent studies have demonstrated that the downstream caspases, such as caspase 3, act
as executors of the apoptotic cascade after traumatic brain injury (TBI) in vivo. However, little …

The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review

AD Bachstetter, JM Morganti, CN Bodnar… - Experimental …, 2020 - Elsevier
In humans, the majority of sustained traumatic brain injuries (TBIs) are classified as 'mild'and
most often a result of a closed head injury (CHI). The effects of a non-penetrating CHI are not …

Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions

MC Liu, F Kobeissy, W Zheng, Z Zhang… - ASN …, 2010 - journals.sagepub.com
Axonally specific microtubule-associated protein tau is an important component of
neurofibrillary tangles found in AD (Alzheimer's disease) and other tauopathy diseases such …