29 Adequate iodide supply and metabolism are essential for thyroid hormones synthesis. 30
In thyrocytes, iodide uptake is mediated by the sodium-iodide symporter (NIS), but several …

Adequate iodide supply and metabolism are essential for thyroid hormones synthesis. In
thyrocytes, iodide uptake is mediated by the sodium-iodide symporter, but several proteins …

In the thyroid, the transport of iodide from the extracellular space to the follicular lumen
requires two steps: the transport in the cell at the basal side and in the lumen at the apical …

Thyroid hormones are essential for normal development and metabolism. Their synthesis
requires transport of iodide into thyroid follicles. The mechanisms involving the apical efflux …

Background: Iodide uptake at the basolateral membrane and iodide efflux at the apical
membrane of thyrocytes, essential steps in the biosynthesis of thyroid hormone, are …

The Pendred syndrome gene encodes a 780-amino acid putative transmembrane protein
(pendrin) that is expressed in the apical membrane of thyroid follicular cells. Although …

Iodide transport by thyrocytes involves porters on the apical and basal surfaces of the cell
facing the follicular lumen and bloodstream, respectively. Recent work identifies pendrin as …

Iodide transport and storage in the thyroid follicles is crucial for thyroid hormone synthesis.
Pendrin, the iodide exporter that transports iodide to thyroid follicles, is responsible for …

Pendred syndrome is an autosomal recessive disorder defined by sensorineural deafness,
goiter and a partial organification defect of iodide. It is caused by biallelic mutations in the …

Thyroid hormones are essential for normal development and metabolism. Thyroid hormone
biosynthesis requires iodide uptake into the thyrocytes and efflux into the follicular lumen …