The mechanisms that modulate the response to tissue injury are not fully understood.
Abnormalities in the repair response are associated with a variety of chronic disease states …

Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in
regulating inflammation. Inflammation is associated with accumulation and turnover of HA …

Inflammation is a complex mechanism that plays a key role during diseases. Dynamic
features of the extracellular matrix (ECM), in particular, during phases of tissue inflammation …

Transition from homeostatic to reactive matrix remodeling is a fundamental adaptive tissue
response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture …

Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and
remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix …

The glycosaminoglycan hyaluronan (HA) is a key component of the microenvironment
surrounding cells. In healthy tissues, HA molecules have extremely high molecular mass …

Hyaluronan is a simple extracellular matrix polysaccharide that actively regulates
inflammation in tissue repair and disease processes. The native HA polymer, which is large …

Hyaluronan is an unbiquitous glycosaminoglycan present in most tissues. Under
homeostatic conditions hyaluronan exists as a high molecular mass polymer that has …

It is well recognized that high molecular weight hyaluronan (H‐HA) exerts potent anti‐
inflammatory effects while its fragmentation into low molecular weight HA (L‐HA) is …

Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …