Microglial cells are the resident macrophages of the central nervous system (CNS). Besides
their classical roles in pathological conditions, these immune cells also dynamically interact …

Neural circuits are constantly monitored and supported by the surrounding microglial cells,
using finely tuned mechanisms which include both direct contact and release of soluble …

Microglial cells participate in brain development and influence neuronal loss and synaptic
maturation. Fractalkine is an important neuronal chemokine whose expression increases …

An essential aspect of normal brain function is the bidirectional interaction and
communication between neurons and neighbouring glial cells. To this end, the brain has …

Microglia have recently been implicated as key regulators of activity‐dependent plasticity,
where they contribute to the removal of inappropriate or excess synapses. However, the …

CX3CR1 is a G protein‐coupled receptor that is expressed exclusively by microglia within
the brain parenchyma. The only known physiological CX3CR1 ligand is the chemokine …

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous
system (CNS) is the leading cause of non-traumatic neurological disability in young adults …

In order to understand processes involved in central nervous system inflammatory diseases,
a critical appreciation of mechanisms involved in the control of immune function in the brain …

Neural and oligodendrocyte precursor cells (NPCs and OPCs) in the subventricular zone
(SVZ) of the brain contribute to oligodendrogenesis throughout life, in part due to direct …

During development, newborn interneurons migrate throughout the embryonic brain. Here,
we provide evidence that these interneurons act in a paracrine fashion to regulate …