The TAM receptor family of TYRO3, AXL and MERTK regulates tissue and immune
homeostasis. Aberrant TAM receptor signalling has been linked to a range of diseases …

Simple Summary In recent years, many studies have shown the importance of TAM kinases
in both normal and neoplastic cells. In this review, we present and discuss the role of the …

Novel treatment approaches are needed to overcome innate and acquired mechanisms of
resistance to current anticancer therapies in cancer cells and the tumour immune …

Receptor tyrosine kinases (RTKs) regulate cellular processes by converting signals from the
extracellular environment to the cytoplasm and nucleus. Tyro3, Axl, and Mer (TAM) receptors …

Simple Summary TAM receptors are a family of receptor tyrosine kinases, comprising Tyro3,
Axl and MerTK. Their primary role is in digestion of dying cells by macrophages without …

The TAM receptor protein tyrosine kinases—Tyro3, Axl, and Mer—are essential regulators of
immune homeostasis. Guided by their cognate ligands Growth arrest-specific gene 6 (Gas6) …

Tyro‐3, Axl, and Mer constitute the TAM family of receptor tyrosine kinases (RTKs)
characterized by a conserved sequence within the kinase domain and adhesion molecule …

Abstract The TAM receptors—TYRO3, AXL, MERTK—are pleiotropically expressed
receptors in both healthy and diseased tissue. A complex of the ligands Protein S (PROS1) …

Tumor-associated macrophages are an abundant cell type in the tumor microenvironment.
These macrophages serve as a promising target for treatment of cancer due to their roles in …

TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, which play
important roles in tumor growth, survival, cell adhesion, as well as innate immunity …