Epigenetic modifications of cytosine residues in the DNA play a critical role for cellular
differentiation and potentially also for aging. In mesenchymal stromal cells (MSC) from …

Within 2–3 months of in vitro culture‐expansion, mesenchymal stromal cells (MSC) undergo
replicative senescence characterized by cell enlargement, loss of differentiation potential …

Background Age-associated changes in genomic DNA methylation have been primarily
attributed to 5-methylcytosine (5mC). However, the recent discovery of 5 …

Replicative senescence has a major impact on function and integrity of cell preparations.
This process is reflected by continuous DNA methylation (DNA m) changes at specific CpG …

Human bone marrow mesenchymal stem cells (MSCs) expanded in vitro exhibit not only a
tendency to lose their proliferative potential, homing ability and telomere length but also …

Cells in culture undergo replicative senescence. In this study, we analyzed functional,
genetic and epigenetic sequels of long-term culture in human mesenchymal stem cells …

In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in
repressive histone post-translational modifications. However, the chromatin marks …

Epigenetic changes represent an attractive mechanism for understanding the phenotypic
changes associated with human aging. Age‐related changes in DNA methylation at the …

Background Altered DNA methylation patterns represent an attractive mechanism for
understanding the phenotypic changes associated with human aging. Several studies have …

A decline in skeletal muscle mass and function with aging is well recognized, but remains
poorly characterized at the molecular level. Here, we report for the first time a genome‐wide …