[HTML][HTML] Specific age-associated DNA methylation changes in human dermal fibroblasts
CM Koch, CV Suschek, Q Lin, S Bork, M Goergens… - PloS one, 2011 - journals.plos.org
Epigenetic modifications of cytosine residues in the DNA play a critical role for cellular
differentiation and potentially also for aging. In mesenchymal stromal cells (MSC) from …
differentiation and potentially also for aging. In mesenchymal stromal cells (MSC) from …
DNA methylation pattern changes upon long‐term culture and aging of human mesenchymal stromal cells
Within 2–3 months of in vitro culture‐expansion, mesenchymal stromal cells (MSC) undergo
replicative senescence characterized by cell enlargement, loss of differentiation potential …
replicative senescence characterized by cell enlargement, loss of differentiation potential …
[HTML][HTML] Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells
EG Toraño, GF Bayón, Á Del Real, MI Sierra… - Journal of Translational …, 2016 - Springer
Background Age-associated changes in genomic DNA methylation have been primarily
attributed to 5-methylcytosine (5mC). However, the recent discovery of 5 …
attributed to 5-methylcytosine (5mC). However, the recent discovery of 5 …
Senescence‐associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells
Replicative senescence has a major impact on function and integrity of cell preparations.
This process is reflected by continuous DNA methylation (DNA m) changes at specific CpG …
This process is reflected by continuous DNA methylation (DNA m) changes at specific CpG …
[HTML][HTML] Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture
MR Choi, YH In, J Park, T Park, KH Jung… - … & molecular medicine, 2012 - nature.com
Human bone marrow mesenchymal stem cells (MSCs) expanded in vitro exhibit not only a
tendency to lose their proliferative potential, homing ability and telomere length but also …
tendency to lose their proliferative potential, homing ability and telomere length but also …
[HTML][HTML] Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks
A Schellenberg, Q Lin, H Schüler, CM Koch… - Aging (Albany …, 2011 - ncbi.nlm.nih.gov
Cells in culture undergo replicative senescence. In this study, we analyzed functional,
genetic and epigenetic sequels of long-term culture in human mesenchymal stem cells …
genetic and epigenetic sequels of long-term culture in human mesenchymal stem cells …
H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells
AF Fernández, GF Bayón, RG Urdinguio… - Genome …, 2015 - genome.cshlp.org
In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in
repressive histone post-translational modifications. However, the chromatin marks …
repressive histone post-translational modifications. However, the chromatin marks …
Reduced DNA methylation patterning and transcriptional connectivity define human skin aging
F Bormann, M Rodríguez‐Paredes, S Hagemann… - Aging cell, 2016 - Wiley Online Library
Epigenetic changes represent an attractive mechanism for understanding the phenotypic
changes associated with human aging. Age‐related changes in DNA methylation at the …
changes associated with human aging. Age‐related changes in DNA methylation at the …
[HTML][HTML] Aging is associated with highly defined epigenetic changes in the human epidermis
G Raddatz, S Hagemann, D Aran, J Söhle… - Epigenetics & …, 2013 - Springer
Background Altered DNA methylation patterns represent an attractive mechanism for
understanding the phenotypic changes associated with human aging. Several studies have …
understanding the phenotypic changes associated with human aging. Several studies have …
Genome‐wide DNA methylation changes with age in disease‐free human skeletal muscle
A Zykovich, A Hubbard, JM Flynn, M Tarnopolsky… - Aging cell, 2014 - Wiley Online Library
A decline in skeletal muscle mass and function with aging is well recognized, but remains
poorly characterized at the molecular level. Here, we report for the first time a genome‐wide …
poorly characterized at the molecular level. Here, we report for the first time a genome‐wide …