Escaping from cell death is one of the adaptations that enable cancer cells to stave off
anticancer therapies. The key players in avoiding apoptosis are collectively known as …

Introduction: Programmed cell death is well-orchestrated process regulated by multiple pro-
apoptotic and anti-apoptotic genes, particularly those of the Bcl-2 gene family. These genes …

The intrinsic apoptosis pathway is controlled by the BCL-2 family of proteins. Although the
prosurvival members of this family can help cancer cells evade apoptosis, they may also …

Most cells express a variety of both anti-apoptotic and pro-apoptotic Bcl-2 proteins and the
interaction within this family dictates whether a cell survives or dies. The dysregulation of the …

Over the last decade the molecular mechanisms controlling programmed cell death
(apoptosis) have become clearer. It appears that many physiological and damage signals …

Inhibition of the chaperone heat-shock protein 90 (HSP90) induces apoptosis, and it is a
promising anti-cancer strategy. The mechanisms underpinning apoptosis activation …

Defects in apoptosis signaling pathways are common in cancer cells. Such defects may play
an important role in tumor initiation because apoptosis normally eliminates cells with …

Members of the BCL-2 family of proteins regulate and execute many cell intrinsic apoptosis
pathways, including those arising from dysregulated expression of cellular oncogenes …

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …

A mechanism for circumventing apoptosis prevalent in many cancer cells is the
overexpression of antiapoptotic BCL-2 family members. Upregulated expression of BCL-2 …