Background. Successful islet transplantation in type 1 diabetes requires tolerance induction
of both allo-and autoreactive T-cell responses. Monoclonal antibodies targeting the CD4 …

We studied the effects of anti-CD4 treatment of diabetic ACI rats on the induction oftolerance
to allogeneic (Lewis) islet allografts. When given as a 4-day treatment regimen, OX38, a …

Clinical islet transplantation is a successful procedure that can improve the quality of life in
recipients with diabetes. A drawback of the procedure is the need for chronic administration …

Background. The prevention of recurrent autoimmunity is a prerequisite for successful islet
transplantation in patients with type I diabetes. Therapies effective in preserving pancreatic β …

Background. T-cell activation and the subsequent induction of effector functions require not
only the recognition of antigen peptides bound to MHC molecules by T-cell receptor (TCR) …

Background Clinical application of islet transplantation to treat type 1 diabetes has been
limited by islet allograft destruction by both allogeneic and autoimmune diabetogenic T-cell …

Grafting autoimmune-diabetic recipients with allogeneic islets, graft rejection and disease
recurrence as major problems of reaching indefinite survival and tolerance induction have to …

Syngeneic pancreatic islet grafts in nonobese diabetic (NOD) mice elicit a cell-mediated
autoimmune response that destroys the insulin-producing [beta] cells in the islet graft. IL-4 …

In addition to providing a large source of donor tissue, xenogeneic islet transplantation might
avoid recurrent autoimmunity in patients with type 1 diabetes. To examine this possibility …

Background. Nonobese diabetic (NOD) mice develop autoimmune diabetes with features
similar to those observed in the human disease. The concurrence of allorecognition and …