Lung cancer is one of the leading causes of cancer mortality worldwide. The therapeutic
effect of chemotherapy is limited due to the resistance of cancer cells, which remains a …

Flap endonuclease 1 (FEN1) plays a crucial role in both DNA replication and damage
repair. In this study, FEN1 expression and its clinical-pathologic significance in non–small …

Abstract DNA flap endonuclease 1 (FEN1) plays critical roles in maintaining genome
stability and integrity by participating in both DNA replication and repair. Suppression of …

DNA damage repair plays a key role in maintaining genomic stability and integrity. Flap
endonuclease 1 (FEN1) is a core protein in the base excision repair (BER) pathway and …

Flap endonuclease 1 (FEN1) is a DNA replication/repair protein involved in Okazaki
fragment processing, long-patch base excision repair, DNA double-strand break repair and …

Abstract Flap endonuclease 1 (FEN1) overexpression promotes breast cancer. We
investigated the role of FEN1 in cisplatin resistance and the chemosensitizing effects of …

As a DNA repair protein, flap endonuclease 1 (FEN1), a structure-specific 5'nuclease, plays
pivotal roles in the maturation of Okazaki fragments, long-patch base excision repair …

Abstract Flap endonuclease-1 (FEN1) is a multifunctional, structure-specific nuclease that
has a critical role in maintaining human genome stability. FEN1 mutations have been …

Background Drug resistance is a major challenge in cancer therapeutics. Abundant
evidence indicates that DNA repair systems are enhanced after repetitive chemotherapeutic …

Abstract Flap endonuclease 1 (FEN1) is a structure-specific nuclease best known for its
critical roles in Okazaki fragment maturation, DNA repair, and apoptosis-induced DNA …