The aim of the study was to determine the size and location of homogeneous
inflamed/noninflamed and inhomogeneous inflamed/noninflamed lung compartments and …

Objective: Neutrophilic inflammation plays a key role in the pathogenesis of acute
respiratory distress syndrome (ARDS) and acute lung injury (ALI). Positron emission …

Objective: The common denominator in most forms of ventilator-induced lung injury is an
intense inflammatory response mediated by neutrophils. PET with [18 F] fluoro-2-deoxy-D …

Objective: To compare the computed tomographic (CT) analysis of the distribution of gas
and tissue in the lungs of patients with ARDS with that in healthy volunteers. Design …

Rationale: The contribution of aeration heterogeneity to lung injury during early mechanical
ventilation of uninjured lungs is unknown. Objectives: To test the hypotheses that a strategy …

Rationale: The ratio of PaO2 to FiO2 (P/F) defines acute respiratory distress syndrome
(ARDS) severity and suggests appropriate therapies. Objectives: We investigated 1) whether …

Rationale: The assessment of lung recruitability in patients with acute respiratory distress
syndrome (ARDS) may be important for planning recruitment maneuvers and setting positive …

Objectives: Acute respiratory distress syndrome is a clinical syndrome characterized by a
refractory hypoxemia due to an inflammatory and high permeability pulmonary edema …

Rationale: During acute lung injury (ALI), mechanical ventilation can aggravate inflammation
by promoting alveolar distension and cyclic recruitment–derecruitment. As an estimate of the …

Rationale: Pressures and volumes needed to induce ventilator-induced lung injury in
healthy lungs are far greater than those applied in diseased lungs. A possible explanation …