The aim of the present study was to determine whether adeno-associated viral vector (AAV)
mediated transfer of ciliary neurotrophic factor (CNTF) and RhoA shRNA has additive effects …

Rat optic nerve (ON) transection leads to mainly apoptotic cell death of about 85% of the
retinal ganglion cell (RGC) population within 14 days after lesion. In the present study, we …

We compared the effects of intravitreal injection of bi-cistronic adeno-associated viral (AAV-
2) vectors encoding enhanced green fluorescent protein (GFP) and either ciliary …

Recombinant adeno-associated viral (rAAV) vectors expressing neurotrophic genes reduce
neuronal death and promote axonal regeneration in central nervous system (CNS) injury …

Intravitreal injections of recombinant ciliary neurotrophic factor (rCNTF) protect adult rat
retinal ganglion cells (RGCs) after injury and stimulate regeneration, an effect enhanced by …

The Rho/ROCK pathway is a promising therapeutic target in neurodegenerative and
neurotraumatic diseases. Pharmacological inhibition of various pathway members has been …

Recombinant adeno-associated viral (rAAV) vectors can be used to introduce neurotrophic
genes into injured CNS neurons, promoting survival and axonal regeneration. Gene therapy …

Retinitis pigmentosa (RP), an inherited retinal degenerative disease causing blindness, is
characterized by progressive apoptotic death of photoreceptors. Therapeutic modification of …

The optic nerve crush injury is a well-accepted model to study the mechanisms of axonal
regeneration after trauma in the CNS. The infection of retinal ganglion cells (RGCs) with an …

Use of viral vectors to deliver therapeutic genes to the central nervous system holds promise
for the treatment of neurodegenerative diseases and neurotrauma. Adeno-associated viral …